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【结 构 式】 
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【分子编号】35624 【品名】(E)-3-(dimethylamino)-1-(2,4,6-trimethoxyphenyl)-2-propen-1-one 【CA登记号】 |
【 分 子 式 】C14H19NO4 【 分 子 量 】265.3092 【元素组成】C 63.38% H 7.22% N 5.28% O 24.12% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)2',4',6'-Trimethoxyacetophenone (I) was condensed with dimethylformamide dimethylacetal (II) in refluxing DMF to afford the enamino ketone (III). Subsequent cyclization of (III) with N1-dicyclopropylmethyl-N1-propyl-guanidine hydrochloride (IV) in the presence of t-BuOK produced the target pyrimidine.
| 【1】 McCarthy, J.R.; Xie, Y.F.; Whitten, J.P.; Webb, T.R.; Chen, C.; Ramphal, J.Y.; Grigoriadis, D.E.; Dagnino, R. Jr.; Huang, C.Q.; Liu, Z. (Neurocrine Biosciences Inc.); Amino-substd. thiadiazoles, pyrimidines, triazines or triazoles useful as CTF receptor antagonists. EP 0846108; JP 1999507358; US 5795905; WO 9639400 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 35623 | 1-(2,4,6-trimethoxyphenyl)-1-ethanone | 832-58-6 | C11H14O4 | 详情 | 详情 |
| (II) | 11984 | N-(Dimethoxymethyl)-N,N-dimethylamine;dimethylformamide dimethylacetal;1,1-dimethoxy-N,N-dimethylmethanamine； Dimethoxy-N,N-dimethylmethanamine; N,N-Dimethylformamide dimethyl acetal | 4637-24-5 | C5H13NO2 | 详情 | 详情 |
| (III) | 35624 | (E)-3-(dimethylamino)-1-(2,4,6-trimethoxyphenyl)-2-propen-1-one | C14H19NO4 | 详情 | 详情 | |
| (IV) | 35625 | N-(dicyclopropylmethyl)-N-propylguanidine | C11H21N3 | 详情 | 详情 |
Extended Information