1-(2,4,6-trimethoxyphenyl)-1-ethanone -Drug Synthesis Database

【结构式】

【分子编号】35623

【品名】1-(2,4,6-trimethoxyphenyl)-1-ethanone

【CA登记号】832-58-6

【分子式】C₁₁H₁₄O₄

【分子量】210.22976

【元素组成】C 62.85% H 6.71% O 30.44%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

2',4',6'-Trimethoxyacetophenone (I) was condensed with dimethylformamide dimethylacetal (II) in refluxing DMF to afford the enamino ketone (III). Subsequent cyclization of (III) with N1-dicyclopropylmethyl-N1-propyl-guanidine hydrochloride (IV) in the presence of t-BuOK produced the target pyrimidine.

参考文献中间体

合成目标

【1】 McCarthy, J.R.; Xie, Y.F.; Whitten, J.P.; Webb, T.R.; Chen, C.; Ramphal, J.Y.; Grigoriadis, D.E.; Dagnino, R. Jr.; Huang, C.Q.; Liu, Z. (Neurocrine Biosciences Inc.); Amino-substd. thiadiazoles, pyrimidines, triazines or triazoles useful as CTF receptor antagonists. EP 0846108; JP 1999507358; US 5795905; WO 9639400 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	35623	1-(2,4,6-trimethoxyphenyl)-1-ethanone	832-58-6	C₁₁H₁₄O₄	详情	详情
(II)	11984	N-(Dimethoxymethyl)-N,N-dimethylamine;dimethylformamide dimethylacetal;1,1-dimethoxy-N,N-dimethylmethanamine； Dimethoxy-N,N-dimethylmethanamine; N,N-Dimethylformamide dimethyl acetal	4637-24-5	C₅H₁₃NO₂	详情	详情
(III)	35624	(E)-3-(dimethylamino)-1-(2,4,6-trimethoxyphenyl)-2-propen-1-one		C₁₄H₁₉NO₄	详情	详情
(IV)	35625	N-(dicyclopropylmethyl)-N-propylguanidine		C₁₁H₂₁N₃	详情	详情

Extended Information