2-(4-methylphenoxy)acetic acid -Drug Synthesis Database

【结构式】

【分子编号】34754

【品名】2-(4-methylphenoxy)acetic acid

【CA登记号】940-64-7

【分子式】C₉H₁₀O₃

【分子量】166.1766

【元素组成】C 65.05% H 6.07% O 28.88%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

The condensation between pyruvic acid (I) and thiocarbohydrazide (II) provided 4-amino-3-mercapto-6-methyl-1,2,4-triazin-5(4H)-one (III). Further ring closure of (III) with (4-methylphenoxy)acetic acid (IV) by means of POCl3 yielded the required thiadiazolo triazinone.

参考文献中间体

合成目标

【1】 Shridhara, K.; Sarojini, B.K.; Holla, B.S.; Antony, G.; Synthesis of some new biologically active thiadiazolotriazinones - Part II. Farmaco 1999, 54, 3, 149.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	24066	2-oxopropionic acid	127-17-3	C₃H₄O₃	详情	详情
(II)	34752	carbonothioic dihydrazide	2231-57-4	CH₆N₄S	详情	详情
(III)	34753	4-amino-6-methyl-3-sulfanyl-1,2,4-triazin-5(4H)-one		C₄H₆N₄OS	详情	详情
(IV)	34754	2-(4-methylphenoxy)acetic acid	940-64-7	C₉H₁₀O₃	详情	详情

Extended Information