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【结 构 式】 
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【分子编号】34646 【品名】tert-butyl (1S)-1-([[(1S)-1-[4-(benzyloxy)benzyl]-2-(tert-butylamino)-2-oxoethyl]amino]carbonyl)-3-methylbutyl(methyl)carbamate 【CA登记号】 |
【 分 子 式 】C32H47N3O5 【 分 子 量 】553.7424 【元素组成】C 69.41% H 8.56% N 7.59% O 14.45% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XII)In a related procedure, N-Boc-N-methylleucine (XI) was coupled with O-benzyltyrosine amide (III) in the presence of HBTU to give the protected dipeptide (XII). Trifluoroacetic acid-promoted cleavage of the Boc group of (XII) provided amine (XIII). Finally, reductive alkylation of (XIII) with 4-tert-butylbenzaldehyde (VII) gave rise to the title compound.
| 【1】 Ryder, T.R.; Hu, L.-Y.; Rafferty, M.F.; et al.; Structure-activity relationship of N-methyl-N-aralkyl-peptidylamines as novel N-type calcium channel blockers. Bioorg Med Chem Lett 1999, 9, 15, 2151. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (III) | 30798 | (2S)-2-amino-3-[4-(benzyloxy)phenyl]-N-(tert-butyl)propanamide | C20H26N2O2 | 详情 | 详情 | |
| (VII) | 16638 | 4-(tert-butyl)benzaldehyde; 4-tert-Butyl-benzaldehyde | 939-97-9 | C11H14O | 详情 | 详情 |
| (XI) | 26295 | (2S)-2-[(tert-butoxycarbonyl)(methyl)amino]-4-methylpentanoic acid | 609-23-4 | C12H23NO4 | 详情 | 详情 |
| (XII) | 34646 | tert-butyl (1S)-1-([[(1S)-1-[4-(benzyloxy)benzyl]-2-(tert-butylamino)-2-oxoethyl]amino]carbonyl)-3-methylbutyl(methyl)carbamate | C32H47N3O5 | 详情 | 详情 | |
| (XIII) | 34647 | (2S)-N-[(1S)-1-[4-(benzyloxy)benzyl]-2-(tert-butylamino)-2-oxoethyl]-4-methyl-2-(methylamino)pentanamide | C27H39N3O3 | 详情 | 详情 |
Extended Information