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【结 构 式】 
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【分子编号】34625 【品名】O-(cyclopropylmethyl)hydroxylamine; 1-[(aminooxy)methyl]cyclopropane 【CA登记号】 |
【 分 子 式 】C4H9NO 【 分 子 量 】87.1216 【元素组成】C 55.15% H 10.41% N 16.08% O 18.36% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)The condensation of 2,3,4-trifluorobenzoic acid (I) with 2-chloro-4-iodoaniline (II) in the presence of LDA in THF afforded the aryl anthranilic acid (III), which was then coupled with O-(cyclopropylmethyl)hydroxylamine (IV) using bromo-tris(pyrrolidino)phosphonium hexafluorophosphate (PyBrOP) to furnish the title hydroxamate.
| 【1】 Tecle, H.; Dudley, D.T.; Bridges, A.J.; Barrett, S.D.; Saltiel, A.R.; Doherty, A.M. (Pfizer Inc.); 4-Bromo or 4-iodo phenylamino benzhydroxamic acid derivs. and their use as MEK inhibitors. EP 0993439; WO 9901426 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 34622 | 2,3,4-trifluorobenzoic acid | 61079-72-9 | C7H3F3O2 | 详情 | 详情 |
| (II) | 34623 | 2-chloro-4-iodophenylamine; 2-chloro-4-iodoaniline | 42016-93-3 | C6H5ClIN | 详情 | 详情 |
| (III) | 34624 | 2-(2-chloro-4-iodoanilino)-3,4-difluorobenzoic acid | C13H7ClF2INO2 | 详情 | 详情 | |
| (IV) | 34625 | O-(cyclopropylmethyl)hydroxylamine; 1-[(aminooxy)methyl]cyclopropane | C4H9NO | 详情 | 详情 |
Extended Information