2,2-dihydroxy-1-(3-thienyl)-1-ethanone -Drug Synthesis Database

【结构式】

【分子编号】34620

【品名】2,2-dihydroxy-1-(3-thienyl)-1-ethanone

【CA登记号】

【分子式】C₆H₆O₃S

【分子量】158.17784

【元素组成】C 45.56% H 3.82% O 30.34% S 20.27%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

Oxidation of 3-acetylthiophene (I) with selenium dioxide in refluxing dioxan provided 3-thienylglyoxaldehyde hydrate (II). This was then condensed with 4,5-dimethoxy-1,2-phenylenediamine (III) in boiling EtOH to produce the target quinoxaline, which was finally isolated as the hydrochloride salt.

参考文献中间体

合成目标

【1】 Myers, M.R.; Maguirre, M.P.; Spada, A.P.; Persons, P.E. (Aventis Pharmaceuticals, Inc.); Bis mono- and bicyclic aryl and heteroaryl cpds. which inhibit EGF and/or PDGF receptor tyrosine kinase. US 5480883 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	34619	1-(3-thienyl)-1-ethanone	1468-83-3	C₆H₆OS	详情	详情
(II)	34620	2,2-dihydroxy-1-(3-thienyl)-1-ethanone		C₆H₆O₃S	详情	详情
(III)	34621	4,5-dimethoxy-1,2-benzenediamine; 2-amino-4,5-dimethoxyphenylamine		C₈H₁₂N₂O₂	详情	详情

Extended Information