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【结 构 式】 
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【药物名称】RPR-101511A 【化学名称】6,7-Dimethoxy-2-(3-thienyl)quinoxaline hydrochloride 【CA登记号】146847-57-6 【 分 子 式 】C14H13ClN2O2S 【 分 子 量 】308.78891 |
【开发单位】Aventis Pharma (Originator) 【药理作用】CARDIOVASCULAR DRUGS, Restenosis Treatment of, Treatment of Disorders of the Coronary Arteries and Atherosclerosis, Tyrosine Kinase Inhibitors |
合成路线1
Oxidation of 3-acetylthiophene (I) with selenium dioxide in refluxing dioxan provided 3-thienylglyoxaldehyde hydrate (II). This was then condensed with 4,5-dimethoxy-1,2-phenylenediamine (III) in boiling EtOH to produce the target quinoxaline, which was finally isolated as the hydrochloride salt.
| 【1】 Myers, M.R.; Maguirre, M.P.; Spada, A.P.; Persons, P.E. (Aventis Pharmaceuticals, Inc.); Bis mono- and bicyclic aryl and heteroaryl cpds. which inhibit EGF and/or PDGF receptor tyrosine kinase. US 5480883 . |
Extended Information