4-allyl-3-benzylphenyl methyl ether; 1-allyl-2-benzyl-4-methoxybenzene -Drug Synthesis Database

【结构式】

【分子编号】34536

【品名】4-allyl-3-benzylphenyl methyl ether; 1-allyl-2-benzyl-4-methoxybenzene

【CA登记号】

【分子式】C₁₇H₁₈O

【分子量】238.32932

【元素组成】C 85.67% H 7.61% O 6.71%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XXIV)

In a further procedure, 2-benzyl-4-methoxyphenol (XXII) was converted to triflate (XXIII), and then allylated to give (XXIV) using allyl tributyl tin. Cleavage of the allylic olefin with ruthenium tetroxide produced carboxylic acid (V). Formation of the acid chloride (VI), followed by Friedel-Crafts cyclization as above afforded tricyclic ketone (VII).

参考文献中间体

合成目标

【1】 Cousins, R.D.; Bondinell, W.E.; Miller, W.H.; et al.; Orally bioavailable nonpeptide vitronectin receptor antagonists with efficacy in an osteoporosis model. Bioorg Med Chem Lett 1999, 9, 13, 1807.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(V)	34518	2-(2-benzyl-4-methoxyphenyl)acetic acid	C₁₆H₁₆O₃	详情	详情
(VI)	34519	2-(2-benzyl-4-methoxyphenyl)acetyl chloride	C₁₆H₁₅ClO₂	详情	详情
(VII)	34520	3-methoxy-5,11-dihydro-10H-dibenzo[a,d]cyclohepten-10-one	C₁₆H₁₄O₂	详情	详情
(XXII)	34534	2-benzyl-4-methoxyphenol	C₁₄H₁₄O₂	详情	详情
(XXIII)	34535	2-benzyl-4-methoxyphenyl trifluoromethanesulfonate	C₁₅H₁₃F₃O₄S	详情	详情
(XXIV)	34536	4-allyl-3-benzylphenyl methyl ether; 1-allyl-2-benzyl-4-methoxybenzene	C₁₇H₁₈O	详情	详情

Extended Information