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【结 构 式】 
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【分子编号】34535 【品名】2-benzyl-4-methoxyphenyl trifluoromethanesulfonate 【CA登记号】 |
【 分 子 式 】C15H13F3O4S 【 分 子 量 】346.3270296 【元素组成】C 52.02% H 3.78% F 16.46% O 18.48% S 9.26% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XXIII)In a further procedure, 2-benzyl-4-methoxyphenol (XXII) was converted to triflate (XXIII), and then allylated to give (XXIV) using allyl tributyl tin. Cleavage of the allylic olefin with ruthenium tetroxide produced carboxylic acid (V). Formation of the acid chloride (VI), followed by Friedel-Crafts cyclization as above afforded tricyclic ketone (VII).
| 【1】 Cousins, R.D.; Bondinell, W.E.; Miller, W.H.; et al.; Orally bioavailable nonpeptide vitronectin receptor antagonists with efficacy in an osteoporosis model. Bioorg Med Chem Lett 1999, 9, 13, 1807. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (V) | 34518 | 2-(2-benzyl-4-methoxyphenyl)acetic acid | C16H16O3 | 详情 | 详情 | |
| (VI) | 34519 | 2-(2-benzyl-4-methoxyphenyl)acetyl chloride | C16H15ClO2 | 详情 | 详情 | |
| (VII) | 34520 | 3-methoxy-5,11-dihydro-10H-dibenzo[a,d]cyclohepten-10-one | C16H14O2 | 详情 | 详情 | |
| (XXII) | 34534 | 2-benzyl-4-methoxyphenol | C14H14O2 | 详情 | 详情 | |
| (XXIII) | 34535 | 2-benzyl-4-methoxyphenyl trifluoromethanesulfonate | C15H13F3O4S | 详情 | 详情 | |
| (XXIV) | 34536 | 4-allyl-3-benzylphenyl methyl ether; 1-allyl-2-benzyl-4-methoxybenzene | C17H18O | 详情 | 详情 |
Extended Information