N-(4-benzoyl-1,5-dimethyl-1H-pyrrol-3-yl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetamide -Drug Synthesis Database

【结构式】

【分子编号】34367

【品名】N-(4-benzoyl-1,5-dimethyl-1H-pyrrol-3-yl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetamide

【CA登记号】

【分子式】C₂₃H₁₉N₃O₄

【分子量】401.42168

【元素组成】C 68.82% H 4.77% N 10.47% O 15.94%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The reaction of 1,2-dimethyl-3-benzoyl-4-aminopyrrole (I) with phthalimidoacetyl chloride (II) by means of NaOH gives 1,2-dimethyl-3-benzoyl-4-(phthalimidoacetamido)pyrrole (III), which is cyclized by reaction with hydrazine in refluxing methanol.

参考文献中间体

合成目标

【1】 Corsico, N.; Tarzia, G.; Fontanella, L.; Mariani, L.; 3,7-Dihydro-5-phenylpyrrolo[3,4-e][1,4]diazepin-2(1H)-ones. Synthesis and pharmaclogical properties. Eur J Med Chem - Chim Ther 1976, 11, 3, 217-220.
【2】 Fontanella, L.; Mariani, L.; Tarzia, G.; Pharmacologically active pyrrolodiazepines. DE 2511599; FR 2264546; GB 1433103; JP 50135094; US 4022766; US 4022766 .
【3】 Castaner, J.; Serradell, M.N.; Premazepam. Drugs Fut 1984, 9, 7, 520.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	34365	N'-(2-ethylbenzoyl)-3-methoxybenzenecarbohydrazonamide		C₁₇H₁₉N₃O₂	详情	详情
(II)	10278	2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)acetyl chloride	6780-38-7	C₁₀H₆ClNO₃	详情	详情
(III)	34367	N-(4-benzoyl-1,5-dimethyl-1H-pyrrol-3-yl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetamide		C₂₃H₁₉N₃O₄	详情	详情

Extended Information