1-(1-cyclohexen-1-yl)-1-ethanone -Drug Synthesis Database

【结构式】

【分子编号】34260

【品名】1-(1-cyclohexen-1-yl)-1-ethanone

【CA登记号】932-66-1

【分子式】C₈H₁₂O

【分子量】124.18268

【元素组成】C 77.38% H 9.74% O 12.88%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VI)

Mannich reaction of acetylcyclohexane (V), paraformaldehyde and 1-norephedrine (I) in the presence of hydrochloric acid yields alifedrine hydrochloride. Mannich reaction of 1-acetylcyclohexene (VI) with paraformaldehyde and (I) followed by catalytic hydrogenation of the resulting beta-aminoketone (III) also gives alifedrine hydrochloride.

参考文献中间体

合成目标

【1】 Engel, J.; et al.; Cycloaliphatic ketoamines. DE 2919495; FR 2426040; GB 2023575; JP 54151950; US 4542159 .
【2】 Bahre, M.; Thiemer, K.; Engel, J.; Breuel, H.P.; Stroman, F.; Kleemann, A.; Alifedrine. Drugs Fut 1984, 9, 10, 727.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	34264	2-amino-1-phenyl-1-propanol		C₉H₁₃NO	详情	详情
(II)	34261	1-(1-cyclohexen-1-yl)-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-1-propanone		C₁₈H₂₅NO₂	详情	详情
(III)	34262	4-methyl-3-[(4-methyl-5-phenyl-1,3-oxazolidin-3-yl)methyl]-5-phenyl-1,3-oxazolidine		C₂₁H₂₆N₂O₂	详情	详情
(V)	34263	1-cyclohexyl-1-ethanone	823-76-7	C₈H₁₄O	详情	详情
(VI)	34260	1-(1-cyclohexen-1-yl)-1-ethanone	932-66-1	C₈H₁₂O	详情	详情

Extended Information