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【结 构 式】

【分子编号】34206

【品名】9-[(2R,5S)-5-[(trityloxy)methyl]tetrahydro-2-furanyl]-9H-purin-6-ylamine; 9-[(2R,5S)-5-[(trityloxy)methyl]tetrahydro-2-furanyl]-9H-purin-6-amine

【CA登记号】

【 分 子 式 】C29H27N5O2

【 分 子 量 】477.56588

【元素组成】C 72.94% H 5.7% N 14.66% O 6.7%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

A new method for the synthesis of title compound has been reported: The reaction of 5'-O-triphenylmethyl-2'-deoxyadenosine (I) with CS2, methyl iodide and NaH gives the corresponding xanthate (II), which is reduced with tributyl hydrogen stannide to 5'-O-triphenylmethyl-2',3'-dideoxyadenosine (III). Finally, this compound is deprotected in the usual way.

1 Samukov, V.V.; Ofitserov, V.I.; Synthesis od 2',3'-dideoxynucleosides. Bioorg Khim 1983, 9, 1, 52-59.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 34204 (2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-2-[(trityloxy)methyl]tetrahydro-3-furanol C29H27N5O3 详情 详情
(II) 34205 O-[(2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-2-[(trityloxy)methyl]tetrahydro-3-furanyl] S-methyl carbonodithioate C31H29N5O3S2 详情 详情
(III) 34206 9-[(2R,5S)-5-[(trityloxy)methyl]tetrahydro-2-furanyl]-9H-purin-6-ylamine; 9-[(2R,5S)-5-[(trityloxy)methyl]tetrahydro-2-furanyl]-9H-purin-6-amine C29H27N5O2 详情 详情
Extended Information