O-[(2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-2-[(trityloxy)methyl]tetrahydro-3-furanyl] S-methyl carbonodithioate -Drug Synthesis Database

【结构式】

【分子编号】34205

【品名】O-[(2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-2-[(trityloxy)methyl]tetrahydro-3-furanyl] S-methyl carbonodithioate

【CA登记号】

【分子式】C₃₁H₂₉N₅O₃S₂

【分子量】583.73516

【元素组成】C 63.79% H 5.01% N 12% O 8.22% S 10.99%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

A new method for the synthesis of title compound has been reported: The reaction of 5'-O-triphenylmethyl-2'-deoxyadenosine (I) with CS2, methyl iodide and NaH gives the corresponding xanthate (II), which is reduced with tributyl hydrogen stannide to 5'-O-triphenylmethyl-2',3'-dideoxyadenosine (III). Finally, this compound is deprotected in the usual way.

参考文献中间体

合成目标

【1】 Samukov, V.V.; Ofitserov, V.I.; Synthesis od 2',3'-dideoxynucleosides. Bioorg Khim 1983, 9, 1, 52-59.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	34204	(2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-2-[(trityloxy)methyl]tetrahydro-3-furanol	C₂₉H₂₇N₅O₃	详情	详情
(II)	34205	O-[(2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-2-[(trityloxy)methyl]tetrahydro-3-furanyl] S-methyl carbonodithioate	C₃₁H₂₉N₅O₃S₂	详情	详情
(III)	34206	9-[(2R,5S)-5-[(trityloxy)methyl]tetrahydro-2-furanyl]-9H-purin-6-ylamine; 9-[(2R,5S)-5-[(trityloxy)methyl]tetrahydro-2-furanyl]-9H-purin-6-amine	C₂₉H₂₇N₅O₂	详情	详情

Extended Information