4-amino-1-butanol -Drug Synthesis Database

【结构式】

【分子编号】33766

【品名】4-amino-1-butanol

【CA登记号】13325-10-5

【分子式】C₄H₁₁NO

【分子量】89.13748

【元素组成】C 53.9% H 12.44% N 15.71% O 17.95%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VII)

Coupling of 4-aminobutanol (VII) with 4-phenylbenzoyl chloride (VIII) produced hydroxy amide (IX). Further Swern oxidation of the alcohol group of (IX) using oxalyl chloride and DMSO afforded aldehyde (X). Finally, reductive condensation of aldehyde (X) with pyrrolidine (VI) in the presence of NaBH(OAc)3 afforded the title compound.

参考文献中间体

合成目标

【1】 Audinot, V.; Dubuffet, T.; Newman-Tancredi, A.; Cussac, D.; Millan, M.J.; Lavielle, G.; Loutz, A.; Novel benzopyrano[3,4-c]pyrrole derivatives as potent and selective dopamine D3 receptor antagonists. Bioorg Med Chem Lett 1999, 9, 14, 2059.
【2】 Lejeune, F.; Hautefaye, P.; Millan, M.; Dubuffet, T.; Lavielle, G. (ADIR et Cie.); Chromene derivs., process for their preparation and pharmaceutical compsns. containing them. EP 0887350; JP 1999071376; US 6090837 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(VI)	33765	(3aR,9bS)-1,2,3,3a,4,9b-hexahydrochromeno[3,4-c]pyrrole-8-carbonitrile		C₁₂H₁₂N₂O	详情	详情
(VII)	33766	4-amino-1-butanol	13325-10-5	C₄H₁₁NO	详情	详情
(VIII)	28439	[1,1'-biphenyl]-4-carbonyl chloride	14002-51-8	C₁₃H₉ClO	详情	详情
(IX)	33767	N-(4-hydroxybutyl)[1,1'-biphenyl]-4-carboxamide		C₁₇H₁₉NO₂	详情	详情
(X)	33768	N-(4-oxobutyl)[1,1'-biphenyl]-4-carboxamide		C₁₇H₁₇NO₂	详情	详情

Extended Information