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【结 构 式】 
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【分子编号】33544 【品名】benzyl 2-methyl-1H-indol-4-yl ether; 4-(benzyloxy)-2-methyl-1H-indole 【CA登记号】 |
【 分 子 式 】C16H15NO 【 分 子 量 】237.30124 【元素组成】C 80.98% H 6.37% N 5.9% O 6.74% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IX)4-Hydroxy-2-methyl-indole (IV) can be quaternized with MeI yielding the ammonium salt (VI), which by heating with aqueous NaCN in converted into 2-cyanomethyl-4-benzyloxyindole (VII). The hydrolysis of (VII) affords the corresponding acid (VIII), which is decarboxylated to 4-benzyloxy-2-methyl-indole (IX). Finally, this compound is hydrogenated to the previously obtained 4-hydroxy-2-methyl-indole (V).
| 【1】 Troxler, F.; Hofmann, A.; Verfahren zur Herstellung neuer Indolderivate. AT 316542B; CH 502337 . |
| 【2】 Weetman, D.F.; Castaner, J.; Mepindolol. Drugs Fut 1978, 3, 5, 381. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IV) | 33539 | N-[[4-(benzyloxy)-1H-indol-2-yl]methyl]-N,N-dimethylamine; [4-(benzyloxy)-1H-indol-2-yl]-N,N-dimethylmethanamine | C18H20N2O | 详情 | 详情 | |
| (V) | 33540 | 4-Hydroxy-2-methylindole; 2-Methyl-1H-indol-4-ol | 35320-67-3 | C9H9NO | 详情 | 详情 |
| (VI) | 33541 | [4-(benzyloxy)-1H-indol-2-yl]-N,N,N-trimethylmethanaminium iodide | C19H23IN2O | 详情 | 详情 | |
| (VII) | 33542 | 2-[4-(benzyloxy)-1H-indol-2-yl]acetonitrile | C17H14N2O | 详情 | 详情 | |
| (VIII) | 33543 | 2-[4-(benzyloxy)-1H-indol-2-yl]acetic acid | C17H15NO3 | 详情 | 详情 | |
| (IX) | 33544 | benzyl 2-methyl-1H-indol-4-yl ether; 4-(benzyloxy)-2-methyl-1H-indole | C16H15NO | 详情 | 详情 |
Extended Information