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【结 构 式】 
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【分子编号】33505 【品名】2-hydroxy-4-(trifluoromethyl)benzoic acid 【CA登记号】328-90-5 |
【 分 子 式 】C8H5F3O3 【 分 子 量 】206.1211096 【元素组成】C 46.62% H 2.45% F 27.65% O 23.29% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)Trifluoromethylphenol (I) is converted into 2-hydroxy-4-trifluoromethylbenzoic acid (II) by treatment with potassium carbonate and carbon dioxide under pressure (Kolbe-Schmitt reaction). (II) is then converted with a suitable acetylating agent in the 2-acetoxy-4-trifluoromethylbenzoic acid (III).
| 【1】 Barra, E.F.; Marin, A.; 4-Trifluoromethylbenzoic acid derivatives as thromboembolic agents. DE 2641556; ES 459855; FR 2354335; GB 1588633; JP 52156831; US 4096252 . |
| 【2】 Marin, A.; Francia, E.; Garcia Rafanell, J.; Triflusal. Drugs Fut 1978, 3, 3, 225. |
Extended Information