Triflusal, UR-1501, Tecnosal, Disgren, -Drug Synthesis Database

【结构式】

【药物名称】Triflusal, UR-1501, Tecnosal, Disgren

【化学名称】2-Acetoxy-4-(trifluoromethyl)benzoic acid
　　　　　　4-(Trifluoromethyl)salicylic acid acetate

【CA登记号】322-79-2

【分子式】C₁₀H₇F₃O₄

【分子量】248.16009

【开发单位】Uriach (Originator), Pfizer (Not Determined)

【药理作用】Alzheimer's Dementia, Treatment of , Antiplatelet Therapy, Coagulation Disorders Therapy, Cognition Disorders, Treatment of, HEMATOLOGIC DRUGS, NEUROLOGIC DRUGS

合成路线1

Trifluoromethylphenol (I) is converted into 2-hydroxy-4-trifluoromethylbenzoic acid (II) by treatment with potassium carbonate and carbon dioxide under pressure (Kolbe-Schmitt reaction). (II) is then converted with a suitable acetylating agent in the 2-acetoxy-4-trifluoromethylbenzoic acid (III).

参考文献中间体

【1】 Barra, E.F.; Marin, A.; 4-Trifluoromethylbenzoic acid derivatives as thromboembolic agents. DE 2641556; ES 459855; FR 2354335; GB 1588633; JP 52156831; US 4096252 .
【2】 Marin, A.; Francia, E.; Garcia Rafanell, J.; Triflusal. Drugs Fut 1978, 3, 3, 225.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	33504	3-(trifluoromethyl)phenol	98-17-9	C₇H₅F₃O	详情	详情
(II)	33505	2-hydroxy-4-(trifluoromethyl)benzoic acid	328-90-5	C₈H₅F₃O₃	详情	详情
(IV)	19273	acetyl chloride	75-36-5	C₂H₃ClO	详情	详情
(V)	33506	ketene	463-51-4	C₂H₂O	详情	详情

Extended Information