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【结 构 式】

【分子编号】39819

【品名】1-[[(chlorocarbonyl)oxy]methyl]-4-methoxybenzene

【CA登记号】

【 分 子 式 】C9H9ClO3

【 分 子 量 】200.62136

【元素组成】C 53.88% H 4.52% Cl 17.67% O 23.92%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(V)

3) By reaction of 4-methoxybenzylamine (I) with methyl isothiocyanate (B) in ether to yield N-(4-methoxybenzyl)-N'-methylthiourea (III), which is then methylated with MeI in refluxing methanol affording N-(4-methoxybenzyl)-N',S-dimethylisothiourea (IV). Finally, this compound is treated first with methylamine in refluxing methanol and then with H2SO4.

1 Castaner, J.; Loren, J.G.; Cefoxitin. Drugs Fut 1978, 3, 6, 434.
2 Christensen, B.G.; Ratcliffe, R.W.; Total synthesis of beta-lactam antibiotics. I. alpha-Thioformamido-diethylphosphonioacetates. Tetrahedron Lett 1973, 46, 4645-48.
3 Christensen, B.G.; Ratcliffe, R.W.; Total synthesis of beta-lactam antibiotics. II. (rac)-Cephalotin. Tetrahedron Lett 1973, 46, 4649-52.
4 Christensen, B.G.; Ratcliffe, R.W. (Merck & Co., Inc.); 7-Azido-cephalosporin compounds and their preparation. DE 2365406; FR 2182953; GB 1424373; JP 49014488 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(B) 10498 Benzaldehyde;Benzoic aldehyde;Phenylmethanal 100-52-7 C7H6O 详情 详情
(A) 12714 diethyl phosphonate; diethyl phosphite 762-04-9 C4H11O3P 详情 详情
(I) 39815 1,3,5-tribenzyl-1,3,5-triazinane 2547-66-2 C24H27N3 详情 详情
(II) 39816 diethyl (benzylamino)methylphosphonate C12H20NO3P 详情 详情
(III) 39817 diethyl aminomethylphosphonate C5H14NO3P 详情 详情
(IV) 39818 diethyl [[(E)-benzylidene]amino]methylphosphonate 50917-73-2 C12H18NO3P 详情 详情
(V) 39819 1-[[(chlorocarbonyl)oxy]methyl]-4-methoxybenzene C9H9ClO3 详情 详情
(VI) 39820 4-methoxybenzyl 2-(diethoxyphosphoryl)-2-[[(E)-benzylidene]amino]acetate C21H26NO6P 详情 详情
(VII) 39821 4-methoxybenzyl 2-amino-2-(diethoxyphosphoryl)acetate C14H22NO6P 详情 详情
(VIII) 39822 O-ethyl thioformate C3H6OS 详情 详情
(IX) 39823 4-methoxybenzyl 2-(diethoxyphosphoryl)-2-(thioformylamino)acetate C15H22NO6PS 详情 详情
(X) 39824 3-chloro-2-oxopropyl acetate 40235-68-5 C5H7ClO3 详情 详情
(XI) 39825 4-methoxybenzyl 5-[(acetoxy)methyl]-6H-1,3-thiazine-4-carboxylate C16H17NO5S 详情 详情
(XII) 39826 2-azidoacetyl chloride C2H2ClN3O 详情 详情
(XIII) 39827 4-methoxybenzyl (6R,7R)-3-[(acetoxy)methyl]-7-azido-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate C18H18N4O6S 详情 详情
(XIV) 39828 4-methoxybenzyl (6R,7R)-3-[(acetoxy)methyl]-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate C18H20N2O6S 详情 详情
(XV) 39829 4-methoxybenzyl (6R,7R)-3-[(acetoxy)methyl]-7-[[(E)-(4-nitrophenyl)methylidene]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate C25H23N3O8S 详情 详情
(C) 18184 4-Nitrobenzaldehyde 555-16-8 C7H5NO3 详情 详情
Extended Information