2-[(2-methyl-1H-imidazol-1-yl)methyl]pyridine -Drug Synthesis Database

【结构式】

【分子编号】37793

【品名】2-[(2-methyl-1H-imidazol-1-yl)methyl]pyridine

【CA登记号】

【分子式】C₁₀H₁₁N₃

【分子量】173.21756

【元素组成】C 69.34% H 6.4% N 24.26%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The compound was obtained by condensation of 2-(chloromethyl)pyridine (I) with 2-methylimidazole (II) in hot DMF. The free base (III) was then treated with fumaric acid in EtOH to produce the title fumarate salt.

参考文献中间体

合成目标

【1】 Giger, R.K.A. (Novartis AG; Novartis Deutschland GmbH); Imidazolylmethyl-pyridines. DE 4131584; EP 0534904; JP 1993194491; US 5635521 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	26187	2-(Chloromethyl)pyridine	4377-33-7	C₆H₆ClN	详情	详情
(II)	15670	2-Methylimidazole; 2-Methyl-1H-imidazole	693-98-1	C₄H₆N₂	详情	详情
(III)	37793	2-[(2-methyl-1H-imidazol-1-yl)methyl]pyridine		C₁₀H₁₁N₃	详情	详情

Extended Information