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【结 构 式】 
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【药物名称】SDZ-NDD-094, NDD-094 【化学名称】Bis[2-(2-methylimidazol-1-ylmethyl)pyridine] trifumarate 【CA登记号】148257-48-1 (free base) 【 分 子 式 】C32H34N6O12 【 分 子 量 】694.66078 |
【开发单位】Novartis (Originator) 【药理作用】Alzheimer's Dementia, Treatment of , Cognition Disorders, Treatment of, NEUROLOGIC DRUGS |
合成路线1
The compound was obtained by condensation of 2-(chloromethyl)pyridine (I) with 2-methylimidazole (II) in hot DMF. The free base (III) was then treated with fumaric acid in EtOH to produce the title fumarate salt.
| 【1】 Giger, R.K.A. (Novartis AG; Novartis Deutschland GmbH); Imidazolylmethyl-pyridines. DE 4131584; EP 0534904; JP 1993194491; US 5635521 . |
Extended Information