|
【结 构 式】 
|
【分子编号】34475 【品名】8-methyl-3-[4-(trifluoromethyl)phenyl]-8-azabicyclo[3.2.1]octan-3-ol 【CA登记号】 |
【 分 子 式 】C15H18F3NO 【 分 子 量 】285.3092696 【元素组成】C 63.15% H 6.36% F 19.98% N 4.91% O 5.61% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)Lithiation of 4-bromobenzotrifluoride (I) by means of butyllithium provided the organolithium derivative (II), which was condensed with 8-methyl-8-azabicyclo[3.2.1]octan-3-one (III) to give the carbinol adduct (IV). Subsequent dehydration of (IV) employing HCl in AcOH produced the title olefin.
| 【1】 Moldt, P.; Scheel-Kruger, J.; Olsen, G.M.; Nielsen, E.O. (NeuroSearch A/S); 8-Azabicyclo[3.2.1]oct-2-ene derivs., their preparation and use. EP 0859777; JP 1998512589; WO 9713770 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 34473 | 1-bromo-4-(trifluoromethyl)benzene | 402-43-7 | C7H4BrF3 | 详情 | 详情 |
| (II) | 34474 | [4-(trifluoromethyl)phenyl]lithium | C7H4F3Li | 详情 | 详情 | |
| (III) | 16443 | (1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-one | C8H13NO | 详情 | 详情 | |
| (IV) | 34475 | 8-methyl-3-[4-(trifluoromethyl)phenyl]-8-azabicyclo[3.2.1]octan-3-ol | C15H18F3NO | 详情 | 详情 |
Extended Information