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【结 构 式】 
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【分子编号】16443 【品名】(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-one 【CA登记号】 |
【 分 子 式 】C8H13NO 【 分 子 量 】139.19736 【元素组成】C 69.03% H 9.41% N 10.06% O 11.49% |
合成路线1
该中间体在本合成路线中的序号：(V)The target compound has been obtained by condensation of 3.3-dimethylindoline-1-carbonyl chloride (IV) with endo-8-methyl-8-azabicyclo[3.2.1]octan-3-amine (II) by means of triethylamine followed by salification with HCl. The intermediates (II) and (IV) have been obtained as follows: A) The metthylation of 3-methylindole (III) with methylmagnesium iodid / methyl iodid, followed by hydrogenation with H2/Pt in acetic acid gives 3,3-dimethylindoline (I), which is then treated with phosghene / Et3N to afford intermediate (IV). B) The reductocondensation of 8-methyl-para-bicyclo[3.2.1]octan-3-one (V) with benzylamine and H2/Pt gives the secondary benzylamine (VI), which is finally deprotected by hydrogenation over Pd/C to give intermediate (II).
| 【1】 Archer, S.; Lewis, T.R.; Unser, M.J.; 3alpha-(2-Diethylaminoethyl)-aminotropane and related compounds. J Am Chem Soc 1957, 79, 4194-8. |
| 【2】 Miyasaka, T.; Mutai, M.; Nokata, K.; Sawada, S.; Sugino, E. (Yakult Honsha Co., Ltd.); New camptothecin derivs. and process for preparing same. EP 0137145; JP 1985019790 . |
| 【3】 Joiner, K.A.; King, F.D. (SmithKline Beecham plc); Certain 2,3-dihydro-indole-1-carboxamido-N-[8-azabicyclo(3.2.1)octan-3-yl] derivatives having 5-HT-antagonist activity. EP 0363466; JP 1990503569; US 4871744; US 5049556; WO 8909217 . |
| 【4】 Blackburn, T.; King, F.; BRL46470A. Drugs Fut 1992, 17, 11, 987. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 12411 | 3,3-Dimethylindoline | C10H13N | 详情 | 详情 | |
| (II) | 12412 | (1R,5S)-8-Methyl-8-azabicyclo[3.2.1]octan-3-amine; (1R,5S)-8-Methyl-8-azabicyclo[3.2.1]oct-3-ylamine | C8H16N2 | 详情 | 详情 | |
| (III) | 63428 | 3-methyl-1H-indole | C9H9N | 详情 | 详情 | |
| (IV) | 12414 | 3,3-Dimethyl-1-indolinecarbonyl chloride | C11H12ClNO | 详情 | 详情 | |
| (V) | 16443 | (1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-one | C8H13NO | 详情 | 详情 | |
| (VI) | 12413 | N-Benzyl-N-[(1R,5S)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]amine; (1R,5S)-N-Benzyl-8-methyl-8-azabicyclo[3.2.1]octan-3-amine | C15H22N2 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(XIII)The reaction of 5-chloro-2-hydroxybenzoic acid (I) with 2-methyl-2-propenyl chloride (II) by means of K2CO3 and KI in hot DMF gives 5-chloro-2-(2-methyl-2-propenyloxy)benzoic acid 2-methyl-2-propenyl ester (III), which is rearranged by heating at 190 C yielding 5-chloro-2-hydroxy-3-(2-methyl-2-propenyl)benzoic acid 2-methyl-2-propenyl ester (IV). The cyclization of (IV) with refluxing 90% formic acid affords 5-chloro-2,2-dimethyl-2,3-dihydrobenzofuran-7-carboxylic acid (V), which is treated with SOCl2 in DMF and condensed with endo-8-methyl-8-azabicyclo[3.2.1]octan-3-amine (VI). The acid intermediate (V) can also be obtained by hydrolysis of the ester (III) with NaOH and tetrabutylammonium bisulfate in refluxing water to give 5-chloro-2-(2-methyl-2-propenyloxy)benzoic acid (VII), which is rearranged by heating at 170 C yielding 5-chloro-2-hydroxy-3-(2-methyl-2-propenyl)benzoic acid (VIII). Finally, (VIII) is cyclized to acid intermediate (V) by a treatment with aqueous refluxing 2.7N HCl. The intermediate endo-8-methyl-8-azabicyclo[3.2.1]octan-3-amine (VI) has been obtained as follows: 2,5-dihydroxytetrahydrofuran (IX) or 2,5-dimethoxytetra-hydrofuran (X) with HCl give butanedialdehyde (XI), which, without isolation, is cyclized with 3-oxoglutaric acid (XII) and methylamine by means of NaOAc and HCl in hot water yielding 8-methyl-8-azabicyclo[3.2.1]octan-3-one (XIII). The reductocondensation of (XIII) with benzylamine by means of NaBH(OAc)3, followed by hydrogenolysis with H2 over Pd/C in basic water gives directly the amine (VI). The intermediate amine (VI) can also be obtained by condensation of bicyclooctanone (XIII) with benzylamine(A) to give the imine (XIV), which is reduced to the benzylamine (XV) with H2 over PtO2 in ethanol. Finally, this compound is debenzylated by hydrogenation over Pd/C in the same solvent yielding amine (VI).
| 【1】 Burks, J.E.; et al.; Development of a manufacturing process for zatosetron maleate. Org Process Res Dev 1997, 1, 3, 198. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (A) | 15147 | Benzylamine; Phenylmethanamine | 100-46-9 | C7H9N | 详情 | 详情 |
| (I) | 13895 | 5-Chloro-2-hydroxybenzoic acid; 5-Chlorosalicylic acid | 321-14-2 | C7H5ClO3 | 详情 | 详情 |
| (II) | 12127 | 3-Chloro-2-methyl-1-propene; Isobutenyl chloride | 563-47-3 | C4H7Cl | 详情 | 详情 |
| (III) | 36355 | 2-methyl-2-propenyl 5-chloro-2-[(2-methyl-2-propenyl)oxy]benzoate | C15H17ClO3 | 详情 | 详情 | |
| (IV) | 36356 | 2-methyl-2-propenyl 5-chloro-2-hydroxy-3-(2-methyl-2-propenyl)benzoate | C15H17ClO3 | 详情 | 详情 | |
| (V) | 13900 | 5-Chloro-2,2-dimethyl-2,3-dihydro-1-benzofuran-7-carboxylic acid | C11H11ClO3 | 详情 | 详情 | |
| (VI) | 12412 | (1R,5S)-8-Methyl-8-azabicyclo[3.2.1]octan-3-amine; (1R,5S)-8-Methyl-8-azabicyclo[3.2.1]oct-3-ylamine | C8H16N2 | 详情 | 详情 | |
| (VII) | 36357 | 5-chloro-2-[(2-methyl-2-propenyl)oxy]benzoic acid | C11H11ClO3 | 详情 | 详情 | |
| (VIII) | 36358 | 5-chloro-2-hydroxy-3-(2-methyl-2-propenyl)benzoic acid | C11H11ClO3 | 详情 | 详情 | |
| (IX) | 36359 | tetrahydro-2,5-furandiol | C4H8O3 | 详情 | 详情 | |
| (X) | 12132 | 2,5-Dimethoxytetrahydrofuran; 5-Methoxytetrahydro-2-furanyl methyl ether | 696-59-3 | C6H12O3 | 详情 | 详情 |
| (XI) | 36360 | succinaldehyde | C4H6O2 | 详情 | 详情 | |
| (XII) | 15530 | 1,3-Acetonedicarboxylic Acid; 3-Oxopentanedioic acid；3-oxoglutaric acid | 542-05-2 | C5H6O5 | 详情 | 详情 |
| (XIII) | 16443 | (1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-one | C8H13NO | 详情 | 详情 | |
| (XIV) | 36361 | N-benzyl-N-[(1R,5S)-8-methyl-8-azabicyclo[3.2.1]oct-3-ylidene]amine; N-[(1R,5S)-8-methyl-8-azabicyclo[3.2.1]oct-3-ylidene](phenyl)methanamine | C15H20N2 | 详情 | 详情 | |
| (XV) | 12413 | N-Benzyl-N-[(1R,5S)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]amine; (1R,5S)-N-Benzyl-8-methyl-8-azabicyclo[3.2.1]octan-3-amine | C15H22N2 | 详情 | 详情 |
合成路线3
该中间体在本合成路线中的序号：rac-(LXXXIII)18) Ring contraction of the tropinone skeleton via a Favorskii rearrangement. Bai et al. utilized the readily available tropinone (LXXIII) as a starting material. Compound (LXXIV), which could be obtained from (LXXIII) in one step, was brominated with cupric bromide to give the monobromide (LXXV). Without separation of the two isomers, both isomers (LXXV) underwent Favorskii rearrangement to yield the expected ester (LXXVI). The key intermediate (LXXVII) was then obtained by selenation of (LXXVI) followed by selenoxide elimination. A palladium-catalyzed Heck-type coupling of (LXXVII) and 2-chloro-5-iodopyridine (LVII) furnished the exo-isomer (LXXVIII) stereoselectively in 56% yield. Conversion of (LXXVIII) to (I) was achieved by radical decarboxylation of the corresponding thiohydroxamic ester followed by cleavage of the carbamate with iodotrimethyl silane.
| 【1】 Bai, D.; Xu, R.; Zhu, X.; Epibatidine. Drugs Fut 1997, 22, 11, 1210. |
| 【2】 Xu, R.; Chu, G.; Bai, D.; Total synthesis of (±)-epibatidine. Tetrahedron Lett 1996, 37, 1463-6. |
| 【3】 Bai, D.; Xu, R.; Chu, G.; Zhu, X.; Synthesis of (±)-epibatidine and its analogues. J Org Chem 1996, 61, 4600-6. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| rac-(LXXXIII) | 16443 | (1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-one | C8H13NO | 详情 | 详情 | |
| rac-(LXXIV) | 16444 | ethyl (1R,5S)-3-oxo-8-azabicyclo[3.2.1]octane-8-carboxylate | 32499-64-2 | C10H15NO3 | 详情 | 详情 |
| rac-(LXXV) | 16445 | ethyl (1R,5S)-2-bromo-3-oxo-8-azabicyclo[3.2.1]octane-8-carboxylate | C10H14BrNO3 | 详情 | 详情 | |
| rac-(LXXVI) | 16446 | ethyl (1R,2S,4S)-2-[(formyloxy)methyl]-7-azabicyclo[2.2.1]heptane-7-carboxylate | C11H17NO4 | 详情 | 详情 | |
| rac-(LXXVII) | 16447 | 7-ethyl 2-methyl (1S,4R)-7-azabicyclo[2.2.1]hept-2-ene-2,7-dicarboxylate | C11H15NO4 | 详情 | 详情 | |
| rac-(LXXVIII) | 16448 | ethyl (1R,2R,3S,4S)-2-(6-chloro-3-pyridinyl)-3-[(formyloxy)methyl]-7-azabicyclo[2.2.1]heptane-7-carboxylate | C16H19ClN2O4 | 详情 | 详情 |
合成路线4
该中间体在本合成路线中的序号：(III)Lithiation of 4-bromobenzotrifluoride (I) by means of butyllithium provided the organolithium derivative (II), which was condensed with 8-methyl-8-azabicyclo[3.2.1]octan-3-one (III) to give the carbinol adduct (IV). Subsequent dehydration of (IV) employing HCl in AcOH produced the title olefin.
| 【1】 Moldt, P.; Scheel-Kruger, J.; Olsen, G.M.; Nielsen, E.O. (NeuroSearch A/S); 8-Azabicyclo[3.2.1]oct-2-ene derivs., their preparation and use. EP 0859777; JP 1998512589; WO 9713770 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 34473 | 1-bromo-4-(trifluoromethyl)benzene | 402-43-7 | C7H4BrF3 | 详情 | 详情 |
| (II) | 34474 | [4-(trifluoromethyl)phenyl]lithium | C7H4F3Li | 详情 | 详情 | |
| (III) | 16443 | (1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-one | C8H13NO | 详情 | 详情 | |
| (IV) | 34475 | 8-methyl-3-[4-(trifluoromethyl)phenyl]-8-azabicyclo[3.2.1]octan-3-ol | C15H18F3NO | 详情 | 详情 |
合成路线5
该中间体在本合成路线中的序号：(I)The reductive alkylation of tropinone (I) with aniline (II) using either NaBH4 or NaBH(OAc)3 as the reducing agent furnished the endo-isomer (III). Arylation of amine (III) with t-butyl 4-bromobenzoate (IV) produced the (diarylamino)tropane (V). Acid cleavage of the tert-butyl ester of (V) gave acid (VI), which was further coupled to diethylamine, yielding amide (VII). Demethylation of tropane (VII) with 1-chloroethyl chloroformate, followed by methanolysis of the resulting carbamate (VIII), provided the secondary amine (IX). This was finally subjected to reductive alkylation with 3,4-methylenedioxybenzaldehyde (X) to give the title compound.
| 【1】 Gauthier, A.D.; Neilson, L.A.; Carson, J.R.; Codd, E.E.; Zhang, S.-P.; Boyd, R.E.; Synthesis and binding affinities of 4-diarylaminotropanes, a new class of delta opioid agonists. Bioorg Med Chem Lett 2000, 10, 10, 1109. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 16443 | (1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-one | C8H13NO | 详情 | 详情 | |
| (II) | 12294 | Aniline; Phenylamine | 62-53-3 | C6H7N | 详情 | 详情 |
| (III) | 51368 | (1R,5S)-8-methyl-N-phenyl-8-azabicyclo[3.2.1]octan-3-amine; N-[(1R,5S)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-N-phenylamine | C14H20N2 | 详情 | 详情 | |
| (IV) | 14286 | tert-butyl 4-bromobenzoate | C11H13BrO2 | 详情 | 详情 | |
| (V) | 51369 | tert-butyl 4-[[(1R,5S)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]anilino]benzoate | C25H32N2O2 | 详情 | 详情 | |
| (VI) | 51370 | 4-[[(1R,5S)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]anilino]benzoic acid | C21H24N2O2 | 详情 | 详情 | |
| (VII) | 51371 | N,N-diethyl-4-[[(1R,5S)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]anilino]benzamide | C25H33N3O | 详情 | 详情 | |
| (VIII) | 51372 | 1-chloroethyl (1R,5S)-3-[4-[(diethylamino)carbonyl](phenyl)anilino]-8-azabicyclo[3.2.1]octane-8-carboxylate | C27H34ClN3O3 | 详情 | 详情 | |
| (IX) | 51373 | 4-[(1R,5S)-8-azabicyclo[3.2.1]oct-3-ylanilino]-N,N-diethylbenzamide | C24H31N3O | 详情 | 详情 | |
| (X) | 10127 | 1,3-Benzodioxole-5-carbaldehyde; Heliotropine | 120-57-0 | C8H6O3 | 详情 | 详情 |
合成路线6
该中间体在本合成路线中的序号：(I)Tropinone (I) is demethylated by treatment with 1-chloroethyl chloroformate, followed by decomposition of the intermediate carbamate in refluxing MeOH. The resultant N-nortropinone (II) is then protected with Boc2O to produce (III). Treatment of N-Boc-nortropinone (III) with N-phenyl trifluoromethanesulfonimide in the presence of potassium bis(trimethylsilyl)amide gives rise to the vinyl triflate (IV), which is further converted to the stannyl derivative (V) with hexamethylditin in the presence of palladium catalyst. Stille coupling of the stannyl compound (V) with ethyl 2-bromobenzoate (VI) produces the aryl tropane derivative (VII). Catalytic hydrogenation of the double bond of (VII) gives rise to a mixture of cis (VIII) and trans (IX) saturated isomers, which are separated by either chromatography or by recrystallization. The desired isomer (VIII) is then deprotected under acidic conditions to furnish the secondary amine (X). Coupling of (X) with (R)-N-Boc-2-amino-5-phenylpentanoic acid (XI) yields amide (XII).
| 【1】 Brinkmann, V.; Hesise, C.E.; Davis, M.D.; et al.; FTY720, a novel therapeutic for transplantation and autoimmunity, targets G-protein-coupled receptors for sphingosine-1-phosphate. 19th Int Congr Transplant Soc (Aug 25 2002, Miami) 2002, Abst 0116. |
| 【2】 Patchett, A.A.; Tata, J.R.; Lu, Z. (Merck & Co., Inc.); Bridged piperidines promote release of growth hormone. US 5731317 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 16443 | (1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-one | C8H13NO | 详情 | 详情 | |
| (II) | 58363 | (1R,5S)-8-azabicyclo[3.2.1]octan-3-one | C7H11NO | 详情 | 详情 | |
| (III) | 58364 | tert-butyl (1R,5S)-3-oxo-8-azabicyclo[3.2.1]octane-8-carboxylate | C12H19NO3 | 详情 | 详情 | |
| (IV) | 58365 | tert-butyl (1S,5R)-3-{[(trifluoromethyl)sulfonyl]oxy}-8-azabicyclo[3.2.1]oct-2-ene-8-carboxylate | C13H18F3NO5S | 详情 | 详情 | |
| (V) | 58366 | tert-butyl (1S,5R)-3-(trimethylstannyl)-8-azabicyclo[3.2.1]oct-2-ene-8-carboxylate | C15H27NO2Sn | 详情 | 详情 | |
| (VI) | 58367 | ethyl 2-bromobenzoate; 2-Bromobenzoic acid ethyl ester | 6091-64-1 | C9H9BrO2 | 详情 | 详情 |
| (VII) | 58368 | tert-butyl (1S,5R)-3-[2-(ethoxycarbonyl)phenyl]-8-azabicyclo[3.2.1]oct-2-ene-8-carboxylate | C21H27NO4 | 详情 | 详情 | |
| (VIII) | 58369 | tert-butyl (1R,5S)-3-[2-(ethoxycarbonyl)phenyl]-8-azabicyclo[3.2.1]octane-8-carboxylate | C21H29NO4 | 详情 | 详情 | |
| (IX) | 58370 | tert-butyl (1R,5S)-3-[2-(ethoxycarbonyl)phenyl]-8-azabicyclo[3.2.1]octane-8-carboxylate | C21H29NO4 | 详情 | 详情 | |
| (X) | 58371 | ethyl 2-[(1R,5S)-8-azabicyclo[3.2.1]oct-3-yl]benzoate | C16H21NO2 | 详情 | 详情 | |
| (XI) | 18468 | (2R)-2-[(tert-butoxycarbonyl)amino]-5-phenylpentanoic acid | C16H23NO4 | 详情 | 详情 | |
| (XII) | 58372 | ethyl 2-((1R,5S)-8-{(2R)-2-[(tert-butoxycarbonyl)amino]-5-phenylpentanoyl}-8-azabicyclo[3.2.1]oct-3-yl)benzoate | C32H42N2O5 | 详情 | 详情 |
合成路线7
该中间体在本合成路线中的序号：(I)Demethylation of tropinone (I) by means of 1-chloroethyl chloroformate, followed by protection of the resultant secondary amine (II) with di-tert-butyl dicarbonate, leads to the N-Boc derivative (III). Treatment of the potassium enolate of (III) with N-phenyl trifluoromethanesulfonimide produces the vinyl triflate (IV), which is then converted to the stannyl derivative (V) upon treatment with hexamethylditin and palladium catalyst. Stille coupling of (V) with ethyl 2-bromobenzoate (VI) affords (VII). After catalytic double bond hydrogenation of (VII), the resultant mixture of diastereoisomers is separated by recrystallization from hexane/ethyl acetate to give (VIII). The N-Boc protecting group of (VIII) is cleaved with HCl in dioxane to yield amine (IX), which is then coupled with N-Boc-D-benzylalanine (X) to furnish amide (XI). Subsequent acidic Boc-group cleavage gives rise to the amine (XII).
| 【1】 Lu, Z.; Tata, J.R.; Cheng, K.; Wei, L.; Chan, W.W.-S.; Butler, B.; Schleim, K.D.; Jacks, T.M.; Hickey, G.; Patchett, A.A.; Substituted bridged phenyl piperidines: Orally active growth hormone secretagogues. Bioorg Med Chem Lett 2003, 13, 10, 1817. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 16443 | (1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-one | C8H13NO | 详情 | 详情 | |
| (II) | 64720 | 8-azabicyclo[3.2.1]octan-3-one | C7H11NO | 详情 | 详情 | |
| (III) | 64721 | 1,1-dimethylethyl 3-oxo-8-azabicyclo[3.2.1]octane-8-carboxylate | C12H19NO3 | 详情 | 详情 | |
| (IV) | 64722 | 1,1-dimethylethyl 3-{[(trifluoromethyl)sulfonyl]oxy}-8-azabicyclo[3.2.1]oct-2-ene-8-carboxylate | C13H18F3NO5S | 详情 | 详情 | |
| (V) | 64723 | 1,1-dimethylethyl 3-(trimethylstannanyl)-8-azabicyclo[3.2.1]oct-2-ene-8-carboxylate | C15H27NO2Sn | 详情 | 详情 | |
| (VI) | 58367 | ethyl 2-bromobenzoate; 2-Bromobenzoic acid ethyl ester | 6091-64-1 | C9H9BrO2 | 详情 | 详情 |
| (VII) | 64724 | 1,1-dimethylethyl 3-{2-[(ethyloxy)carbonyl]phenyl}-8-azabicyclo[3.2.1]oct-2-ene-8-carboxylate | C21H27NO4 | 详情 | 详情 | |
| (VIII) | 64725 | 1,1-dimethylethyl 3-{2-[(ethyloxy)carbonyl]phenyl}-8-azabicyclo[3.2.1]octane-8-carboxylate | C21H29NO4 | 详情 | 详情 | |
| (IX) | 64726 | ethyl 2-(8-azabicyclo[3.2.1]oct-3-yl)benzoate | C16H21NO2 | 详情 | 详情 | |
| (X) | 52886 | Boc-(-)-alpha-amino-4-phenylbutyric acid; Boc-D-Homophenylalanine | 82732-07-8 | C15H21NO4 | 详情 | 详情 |
| (XI) | 64727 | ethyl 2-{8-[2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-4-phenylbutanoyl]-8-azabicyclo[3.2.1]oct-3-yl}benzoate | C31H40N2O5 | 详情 | 详情 | |
| (XII) | 64728 | ethyl 2-[8-(2-amino-4-phenylbutanoyl)-8-azabicyclo[3.2.1]oct-3-yl]benzoate | C26H32N2O3 | 详情 | 详情 |