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【结 构 式】

【分子编号】32965

【品名】3-butoxy-4-(tert-pentylamino)-3-cyclobutene-1,2-dione

【CA登记号】

【 分 子 式 】C13H21NO3

【 分 子 量 】239.31468

【元素组成】C 65.25% H 8.84% N 5.85% O 20.06%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(VIII)

Treatment of 3,4-dibutoxy-3-cyclobutene-1,2-dione (VI) with 1,1-dimethylpropylamine (VII) yielded the amino cyclobutenedione (VIII). Subsequent condensation of (VIII) with 3-chloro-4-(aminomethyl)benzonitrile (V) in THF provided the target diamino derivative.

1 Antane, M.M.; Herbst, D.R.; McFarlane, G.R.; Gundersen, E.G.; Hirth, B.H.; Quagliato, D.A.; Graceffa, R.F.; Butera, J.A.; Gilbert, A.M. (American Home Products Corp.); Substd. N-arylmethylamino derivs. of cyclobutene-3, 4-diones. US 5763474; US 5780505; WO 9802413 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(V) 32962 4-(aminomethyl)-3-chlorobenzonitrile C8H7ClN2 详情 详情
(VI) 32963 3,4-dibutoxy-3-cyclobutene-1,2-dione 2892-62-8 C12H18O4 详情 详情
(VII) 24439 2-methyl-2-butanamine 594-39-8 C5H13N 详情 详情
(VIII) 32965 3-butoxy-4-(tert-pentylamino)-3-cyclobutene-1,2-dione C13H21NO3 详情 详情
Extended Information