5,7-bis(allyloxy)-2-[3-(allyloxy)-4-methoxyphenyl]-4H-chromen-4-one -Drug Synthesis Database

【结构式】

【分子编号】32941

【品名】5,7-bis(allyloxy)-2-[3-(allyloxy)-4-methoxyphenyl]-4H-chromen-4-one

【CA登记号】

【分子式】C₂₅H₂₄O₆

【分子量】420.46196

【元素组成】C 71.42% H 5.75% O 22.83%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

The alkylation of diosmetin (I) with allyl bromide in the presence of NaH in DMF furnished the triallyl ether (II). Claisen rearrangement of (II) in refluxing trichlorobenzene then gave the title compound.

参考文献中间体

合成目标

【1】 Wierzbicki, M.; Boussard, M.-F.; Verbeuren, T.; Vallez, M.-O.; Canet, E.; Rolland, Y. (ADIR et Cie.); Diosmetin derivs., process for their preparation and pharmaceutical compsns. containing them. CA 2161297; EP 0709383; FR 2726273; JP 1996225563; US 5629339 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
	11463	3-Bromo-1-propene; 3-Bromopropene；allyl bromide	106-95-6	C₃H₅Br	详情	详情
(I)	30012	5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one	520-34-3	C₁₆H₁₂O₆	详情	详情
(II)	32941	5,7-bis(allyloxy)-2-[3-(allyloxy)-4-methoxyphenyl]-4H-chromen-4-one		C₂₅H₂₄O₆	详情	详情

Extended Information