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【结 构 式】 
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【药物名称】S-17834 【化学名称】6,8-Diallyl-2-(2-allyl-3-hydroxy-4-methoxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one 【CA登记号】178367-40-3 【 分 子 式 】C25H24O6 【 分 子 量 】420.46643 |
【开发单位】Servier (Originator) 【药理作用】CARDIOVASCULAR DRUGS, Peripheral Vascular Disease, Treatment of, Cell Adhesion Inhibitors, E-Selectin Inhibitors, P-Selectin Inhibitors, VCAM-1 Antagonists |
合成路线1
The alkylation of diosmetin (I) with allyl bromide in the presence of NaH in DMF furnished the triallyl ether (II). Claisen rearrangement of (II) in refluxing trichlorobenzene then gave the title compound.
| 【1】 Wierzbicki, M.; Boussard, M.-F.; Verbeuren, T.; Vallez, M.-O.; Canet, E.; Rolland, Y. (ADIR et Cie.); Diosmetin derivs., process for their preparation and pharmaceutical compsns. containing them. CA 2161297; EP 0709383; FR 2726273; JP 1996225563; US 5629339 . |
Extended Information