【结 构 式】 |
【分子编号】32707 【品名】2-benzylphenol 【CA登记号】28994-41-4 |
【 分 子 式 】C13H12O 【 分 子 量 】184.23768 【元素组成】C 84.75% H 6.57% O 8.68% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(I)The reaction of 2-hydroxydiphenylmethane (I) with 1,4-dibromobutane (II) in a basic medium affords 2-(4-bromobutoxy)diphenylmethane (III), which is then condensed with methylamine in water - ethanol at room temperature.
【1】 Kikumoto, R.; et al.; Pharmaceutically active 2-omega-aminoalkoxydiphenylmethanes. US 4091114 . |
【2】 Kikumoto, R.; et al.; 2-Substituted-1-(omega-aminoalkoxy)benzenes. DE 2627227; FR 2315913; NL 7606668 . |
【3】 Kikumoto, R.; et al. (Mitsubishi Chemical Corp.); Process for preparation of 2-(omega-aminoalkyloxy)diphenylmethanes. JP 52033658 . |
【4】 Serradell, M.N.; Blancafort, P.; Castaner, J.; MCI-2016. Drugs Fut 1980, 5, 12, 611. |
Extended Information