Bifemelane Hydrochloride, BFM-2703, E-0687, MCI-2016, Celeport, Alnert, -Drug Synthesis Database

【结构式】

【药物名称】Bifemelane Hydrochloride, BFM-2703, E-0687, MCI-2016, Celeport, Alnert

【化学名称】N-Methyl-4-[2-(phenylmethyl)phenoxy]-1-butanamine hydrochloride
　　　　　　2-(4-Methylaminobutoxy)diphenylmethane hydrochloride

【CA登记号】62232-46-6, 90293-01-9 (free base)

【分子式】C₁₈H₂₄ClNO

【分子量】305.85108

【开发单位】Eisai (Originator), Mitsubishi Chemical (Originator), Fujisawa (Licensee)

【药理作用】Cognition Disorders, Treatment of, NEUROLOGIC DRUGS

合成路线1

The reaction of 2-hydroxydiphenylmethane (I) with 1,4-dibromobutane (II) in a basic medium affords 2-(4-bromobutoxy)diphenylmethane (III), which is then condensed with methylamine in water - ethanol at room temperature.

参考文献中间体

【1】 Kikumoto, R.; et al.; Pharmaceutically active 2-omega-aminoalkoxydiphenylmethanes. US 4091114 .
【2】 Kikumoto, R.; et al.; 2-Substituted-1-(omega-aminoalkoxy)benzenes. DE 2627227; FR 2315913; NL 7606668 .
【3】 Kikumoto, R.; et al. (Mitsubishi Chemical Corp.); Process for preparation of 2-(omega-aminoalkyloxy)diphenylmethanes. JP 52033658 .
【4】 Serradell, M.N.; Blancafort, P.; Castaner, J.; MCI-2016. Drugs Fut 1980, 5, 12, 611.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	32707	2-benzylphenol	28994-41-4	C₁₃H₁₂O	详情	详情
(II)	11883	1,4-Dibromobutane; 1,4-Butylene bromide	110-52-1	C₄H₈Br₂	详情	详情
(III)	32708	1-benzyl-2-(4-bromobutoxy)benzene; 2-benzylphenyl 4-bromobutyl ether		C₁₇H₁₉BrO	详情	详情

Extended Information