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【结 构 式】

【分子编号】32702

【品名】1-allyl-4-azepanone

【CA登记号】

【 分 子 式 】C9H15NO

【 分 子 量 】153.22424

【元素组成】C 70.55% H 9.87% N 9.14% O 10.44%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(I)

The bromination of 1-allylhexahydro-4H-azepin-4-one (I) with Br2 in acetic acid gives 1-allyl-5-bromohexahydro-4H-azepin-4-one (II), which is cyclized with thiourea (III) in refluxing ethanol.

1 Griss, G.; et al. (Boehringer Ingelheim GmbH); 2-Amino-4,5,7,8-tetrahydro-6H-thiazolo or oxazolo[5,4-d]azepines and salts. ES 396454; FR 2102192; GB 1321509; NL 7111176; US 3804849 .
2 Serradell, M.N.; Blancafort, P.; Castaner, J.; Thorpe, P.J.; B-HT-920. Drugs Fut 1980, 5, 10, 481.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 32702 1-allyl-4-azepanone C9H15NO 详情 详情
(II) 32703 1-allyl-5-bromo-4-azepanone C9H14BrNO 详情 详情
(III) 10180 Thiourea 62-56-6 CH4N2S 详情 详情
Extended Information