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【结 构 式】 
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【药物名称】Talipexole dihydrochloride, BHT-920, B-HT-920, Domin 【化学名称】6-Allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepine dihydrochloride 【CA登记号】36085-73-1, 101626-70-4 (free base) 【 分 子 式 】C10H17Cl2N3S 【 分 子 量 】282.23709 |
【开发单位】Boehringer Ingelheim (Originator) 【药理作用】Antiparkinsonian Drugs, Extrapyramidal Disorders, Treatment of, NEUROLOGIC DRUGS, alpha2-Adrenoceptor Agonists, Dopamine Autoreceptor Agonists, Dopamine D2 Agonists |
合成路线1
The bromination of 1-allylhexahydro-4H-azepin-4-one (I) with Br2 in acetic acid gives 1-allyl-5-bromohexahydro-4H-azepin-4-one (II), which is cyclized with thiourea (III) in refluxing ethanol.
| 【1】 Griss, G.; et al. (Boehringer Ingelheim GmbH); 2-Amino-4,5,7,8-tetrahydro-6H-thiazolo or oxazolo[5,4-d]azepines and salts. ES 396454; FR 2102192; GB 1321509; NL 7111176; US 3804849 . |
| 【2】 Serradell, M.N.; Blancafort, P.; Castaner, J.; Thorpe, P.J.; B-HT-920. Drugs Fut 1980, 5, 10, 481. |
Extended Information