4-(4-chlorobenzyl)-1(2H)-phthalazinone -Drug Synthesis Database

【结构式】

【分子编号】32682

【品名】4-(4-chlorobenzyl)-1(2H)-phthalazinone

【CA登记号】

【分子式】C₁₅H₁₁ClN₂O

【分子量】270.71792

【元素组成】C 66.55% H 4.1% Cl 13.1% N 10.35% O 5.91%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

The cyclization of alpha-(p-chlorophenyl)acetophenone-o-carboxylic acid (I) with hydrazine sulfate by means of NaOH in water gives 4-(p-chlorobenzyl)-1-(2H)-phthalazinone (II), which is then condensed with 2-(2-chloroethyl)-N-methylpyrrolidine (III) by means of NaOH in hot water.

参考文献中间体

合成目标

【1】 Vogelsong, D.; et al.; Basically substituted benzyl phthalazone derivatives acid salts thereof and process for the production thereof. US 3813384 .
【2】 Hillier, K.; Blancafort, P.; Castaner, J.; Serradell, M.N.; Azelastine. Drugs Fut 1980, 5, 3, 123.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	32681	2-[2-(4-Chlorophenyl)acetyl]benzoic acid; alpha-(p-Chlorophenyl)acetophenone-o-carboxylic acid	53242-76-5	C₁₅H₁₁ClO₃	详情	详情
(II)	32682	4-(4-chlorobenzyl)-1(2H)-phthalazinone		C₁₅H₁₁ClN₂O	详情	详情
(III)	30816	2-(2-chloroethyl)-1-methylpyrrolidine		C₇H₁₄ClN	详情	详情

Extended Information