【结 构 式】 |
【分子编号】32681 【品名】2-[2-(4-Chlorophenyl)acetyl]benzoic acid; alpha-(p-Chlorophenyl)acetophenone-o-carboxylic acid 【CA登记号】53242-76-5 |
【 分 子 式 】C15H11ClO3 【 分 子 量 】274.70324 【元素组成】C 65.59% H 4.04% Cl 12.91% O 17.47% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(I)The cyclization of alpha-(p-chlorophenyl)acetophenone-o-carboxylic acid (I) with hydrazine sulfate by means of NaOH in water gives 4-(p-chlorobenzyl)-1-(2H)-phthalazinone (II), which is then condensed with 2-(2-chloroethyl)-N-methylpyrrolidine (III) by means of NaOH in hot water.
【1】 Vogelsong, D.; et al.; Basically substituted benzyl phthalazone derivatives acid salts thereof and process for the production thereof. US 3813384 . |
【2】 Hillier, K.; Blancafort, P.; Castaner, J.; Serradell, M.N.; Azelastine. Drugs Fut 1980, 5, 3, 123. |
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