Retinoyl chloride; (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoyl chloride -Drug Synthesis Database

【结构式】

【分子编号】32680

【品名】Retinoyl chloride; (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoyl chloride

【CA登记号】

【分子式】C₂₀H₂₇ClO

【分子量】318.88648

【元素组成】C 75.33% H 8.53% Cl 11.12% O 5.02%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

The reaction of retinoic acid (I) with PCl3 in dry benzene gives the corresponding retinoyl chloride (II), which is then condensed with 4-aminophenol (III) in DMF - ether.

参考文献中间体

合成目标

【1】 Gander, R.J.; Gurney, J.A.; Esters of retinoic acid. BE 0847942; CA 1062700; GB 1543824; NL 7612201; US 4108880 .
【2】 Hillier, K.; Blancafort, P.; Serradell, M.N.; Castaner, J.; 4-Hydroxyphenylretinamide. Drugs Fut 1980, 5, 3, 132.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	32679	(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid; Retinoic acid	302-79-4	C₂₀H₂₈O₂	详情	详情
(II)	32680	Retinoyl chloride; (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoyl chloride		C₂₀H₂₇ClO	详情	详情
(III)	15715	4-Aminophenol	123-30-8	C₆H₇NO	详情	详情

Extended Information