【结 构 式】 |
【药物名称】Fenretinide, NSC-374551, McN-R-1967, HPR, 4-HPR 【化学名称】N-(4-Hydroxyphenyl)-all-trans-retinamide 【CA登记号】65646-68-6 【 分 子 式 】C26H33NO2 【 分 子 量 】391.55841 |
【开发单位】National Cancer Institute (Originator), R.W. Johnson (Originator) 【药理作用】Bladder Cancer Therapy , Brain Cancer Therapy, Breast Cancer Therapy, Lung Cancer Therapy, Oncolytic Drugs, Ovarian Cancer Therapy, Prostate Cancer Therapy, Solid Tumors Therapy, Apoptosis Inducers, Retinoid RARbeta Agonists, Retinoid RARgamma Agonists, Retinoids |
合成路线1
The reaction of retinoic acid (I) with PCl3 in dry benzene gives the corresponding retinoyl chloride (II), which is then condensed with 4-aminophenol (III) in DMF - ether.
【1】 Gander, R.J.; Gurney, J.A.; Esters of retinoic acid. BE 0847942; CA 1062700; GB 1543824; NL 7612201; US 4108880 . |
【2】 Hillier, K.; Blancafort, P.; Serradell, M.N.; Castaner, J.; 4-Hydroxyphenylretinamide. Drugs Fut 1980, 5, 3, 132. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 32679 | (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid; Retinoic acid | 302-79-4 | C20H28O2 | 详情 | 详情 |
(II) | 32680 | Retinoyl chloride; (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoyl chloride | C20H27ClO | 详情 | 详情 | |
(III) | 15715 | 4-Aminophenol | 123-30-8 | C6H7NO | 详情 | 详情 |
Extended Information