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【结 构 式】

【药物名称】Fenretinide, NSC-374551, McN-R-1967, HPR, 4-HPR

【化学名称】N-(4-Hydroxyphenyl)-all-trans-retinamide

【CA登记号】65646-68-6

【 分 子 式 】C26H33NO2

【 分 子 量 】391.55841

【开发单位】National Cancer Institute (Originator), R.W. Johnson (Originator)

【药理作用】Bladder Cancer Therapy , Brain Cancer Therapy, Breast Cancer Therapy, Lung Cancer Therapy, Oncolytic Drugs, Ovarian Cancer Therapy, Prostate Cancer Therapy, Solid Tumors Therapy, Apoptosis Inducers, Retinoid RARbeta Agonists, Retinoid RARgamma Agonists, Retinoids

合成路线1

The reaction of retinoic acid (I) with PCl3 in dry benzene gives the corresponding retinoyl chloride (II), which is then condensed with 4-aminophenol (III) in DMF - ether.

1 Gander, R.J.; Gurney, J.A.; Esters of retinoic acid. BE 0847942; CA 1062700; GB 1543824; NL 7612201; US 4108880 .
2 Hillier, K.; Blancafort, P.; Serradell, M.N.; Castaner, J.; 4-Hydroxyphenylretinamide. Drugs Fut 1980, 5, 3, 132.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 32679 (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid; Retinoic acid 302-79-4 C20H28O2 详情 详情
(II) 32680 Retinoyl chloride; (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoyl chloride C20H27ClO 详情 详情
(III) 15715 4-Aminophenol 123-30-8 C6H7NO 详情 详情
Extended Information