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【结 构 式】 
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【分子编号】32673 【品名】1-[2-chloro-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole 【CA登记号】 |
【 分 子 式 】C11H9Cl3N2 【 分 子 量 】275.56404 【元素组成】C 47.95% H 3.29% Cl 38.6% N 10.17% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)The reaction of 2,4-dichlorophenacyl chloride (I) with imidazole (A) gives the ketone (II), which is reduced with sodium borohydride to yield the alcohol (III). Conversion of the alcohol (III) to the chloro derivative (IV) with thionylchloride followed by reaction with p-chlorobenzyl mercaptan (V) affords sulconazole.
| 【1】 Keisu, E.E. U.; Manufacture of novel imidazole derivative. AT 347449B; BE 0833614; JP 59089667; ZA 7505100 . |
| 【2】 Arya, V.P.; Sulconazole. Drugs Fut 1980, 5, 4, 206. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (A) | 10255 | Imidazole; 1H-Imidazole | 288-32-4 | C3H4N2 | 详情 | 详情 |
| (I) | 31092 | 2,2',4'-trichloroacetophenone; 2-chloro-1-(2,4-dichlorophenyl)-1-ethanone | 4252-78-2 | C8H5Cl3O | 详情 | 详情 |
| (II) | 32200 | 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-1-ethanone | 46503-52-0 | C11H8Cl2N2O | 详情 | 详情 |
| (III) | 14550 | 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-1-ethanol; alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol; 1-(2',4'-Dichlorophenyl)-2-(1-imidazolyl)ethanol | 24155-42-8 | C11H10Cl2N2O | 详情 | 详情 |
| (IV) | 32673 | 1-[2-chloro-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole | C11H9Cl3N2 | 详情 | 详情 | |
| (V) | 32674 | (4-chlorophenyl)methanethiol; 4-chlorobenzylhydrosulfide | 6258-66-8 | C7H7ClS | 详情 | 详情 |
Extended Information