• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】32603

【品名】methyl 3-[6-[[(4-chlorophenyl)sulfonyl]amino]-2-[2-(nitrooxy)ethyl]-5,6,7,8-tetrahydro-1-naphthalenyl]propanoate

【CA登记号】

【 分 子 式 】C22H25ClN2O7S

【 分 子 量 】496.96848

【元素组成】C 53.17% H 5.07% Cl 7.13% N 5.64% O 22.54% S 6.45%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XIII)

Hydroboration of the vinyl group of (X), followed by oxidative treatment with sodium perborate furnished alcohol (XI), which was further activated as the corresponding tosylate (XII). Displacement of the tosylate group of (XII) with tetrabutylammonium nitrate in toluene gave nitrate ester (XIII). The methyl ester group of (XIII) was finally hydrolyzed with NaOH to the target carboxylic acid.

1 Lavielle, G.; Cimetiere, B.; Verbeuren, T.; Simonet, S.; Descombes, J.-J. (ADIR et Cie.); Nouveaux dérivés de benzènsessulfonylamine, leur procédé depréparation et les compositions pharmaceutiques qui les contiennent. EP 0864561 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(X) 32600 methyl 3-(6-[[(4-chlorophenyl)sulfonyl]amino]-2-vinyl-5,6,7,8-tetrahydro-1-naphthalenyl)propanoate C22H24ClNO4S 详情 详情
(XI) 32601 methyl 3-[6-[[(4-chlorophenyl)sulfonyl]amino]-2-(2-hydroxyethyl)-5,6,7,8-tetrahydro-1-naphthalenyl]propanoate C22H26ClNO5S 详情 详情
(XII) 32602 methyl 3-[6-[[(4-chlorophenyl)sulfonyl]amino]-2-(2-[[(4-methylphenyl)sulfonyl]oxy]ethyl)-5,6,7,8-tetrahydro-1-naphthalenyl]propanoate C29H32ClNO7S2 详情 详情
(XIII) 32603 methyl 3-[6-[[(4-chlorophenyl)sulfonyl]amino]-2-[2-(nitrooxy)ethyl]-5,6,7,8-tetrahydro-1-naphthalenyl]propanoate C22H25ClN2O7S 详情 详情
Extended Information