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【结 构 式】 
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【分子编号】32601 【品名】methyl 3-[6-[[(4-chlorophenyl)sulfonyl]amino]-2-(2-hydroxyethyl)-5,6,7,8-tetrahydro-1-naphthalenyl]propanoate 【CA登记号】 |
【 分 子 式 】C22H26ClNO5S 【 分 子 量 】451.97088 【元素组成】C 58.46% H 5.8% Cl 7.84% N 3.1% O 17.7% S 7.09% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XI)Hydroboration of the vinyl group of (X), followed by oxidative treatment with sodium perborate furnished alcohol (XI), which was further activated as the corresponding tosylate (XII). Displacement of the tosylate group of (XII) with tetrabutylammonium nitrate in toluene gave nitrate ester (XIII). The methyl ester group of (XIII) was finally hydrolyzed with NaOH to the target carboxylic acid.
| 【1】 Lavielle, G.; Cimetiere, B.; Verbeuren, T.; Simonet, S.; Descombes, J.-J. (ADIR et Cie.); Nouveaux dérivés de benzènsessulfonylamine, leur procédé depréparation et les compositions pharmaceutiques qui les contiennent. EP 0864561 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (X) | 32600 | methyl 3-(6-[[(4-chlorophenyl)sulfonyl]amino]-2-vinyl-5,6,7,8-tetrahydro-1-naphthalenyl)propanoate | C22H24ClNO4S | 详情 | 详情 | |
| (XI) | 32601 | methyl 3-[6-[[(4-chlorophenyl)sulfonyl]amino]-2-(2-hydroxyethyl)-5,6,7,8-tetrahydro-1-naphthalenyl]propanoate | C22H26ClNO5S | 详情 | 详情 | |
| (XII) | 32602 | methyl 3-[6-[[(4-chlorophenyl)sulfonyl]amino]-2-(2-[[(4-methylphenyl)sulfonyl]oxy]ethyl)-5,6,7,8-tetrahydro-1-naphthalenyl]propanoate | C29H32ClNO7S2 | 详情 | 详情 | |
| (XIII) | 32603 | methyl 3-[6-[[(4-chlorophenyl)sulfonyl]amino]-2-[2-(nitrooxy)ethyl]-5,6,7,8-tetrahydro-1-naphthalenyl]propanoate | C22H25ClN2O7S | 详情 | 详情 |
Extended Information