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【结 构 式】

【分子编号】32513

【品名】4-([1,1'-biphenyl]-4-yloxy)-3-fluorobenzaldehyde

【CA登记号】

【 分 子 式 】C19H13FO2

【 分 子 量 】292.3094232

【元素组成】C 78.07% H 4.48% F 6.5% O 10.95%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

The arylation of 4-phenylphenol (I) with 3,4-difluorobenzaldehyde (II) in the presence of K2CO3 in hot DMSO afforded diary ether (III). The target carboxylic acid was then obtained by oxidation of the aldehyde group of (III) by means of Ag2O, generated from AgNO3 and NaOH.

1 Fujii, M.; Naito, R.; Oritani, H.; Kimura, T.; Koutoku, H.; Hara, H.; Igarashi, S.; Mase, T.; A novel class of inhibitors for human steroid 5alpha-reductase: Phenoxybenzoic acid derivatives. I. Chem Pharm Bull 1999, 47, 8, 1073.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 32511 [1,1'-biphenyl]-4-ol 92-69-3 C12H10O 详情 详情
(II) 26654 3,4-difluorobenzaldehyde 34036-07-2 C7H4F2O 详情 详情
(III) 32513 4-([1,1'-biphenyl]-4-yloxy)-3-fluorobenzaldehyde C19H13FO2 详情 详情
Extended Information