【结 构 式】 |
【分子编号】32513 【品名】4-([1,1'-biphenyl]-4-yloxy)-3-fluorobenzaldehyde 【CA登记号】 |
【 分 子 式 】C19H13FO2 【 分 子 量 】292.3094232 【元素组成】C 78.07% H 4.48% F 6.5% O 10.95% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(III)The arylation of 4-phenylphenol (I) with 3,4-difluorobenzaldehyde (II) in the presence of K2CO3 in hot DMSO afforded diary ether (III). The target carboxylic acid was then obtained by oxidation of the aldehyde group of (III) by means of Ag2O, generated from AgNO3 and NaOH.
【1】 Fujii, M.; Naito, R.; Oritani, H.; Kimura, T.; Koutoku, H.; Hara, H.; Igarashi, S.; Mase, T.; A novel class of inhibitors for human steroid 5alpha-reductase: Phenoxybenzoic acid derivatives. I. Chem Pharm Bull 1999, 47, 8, 1073. |
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