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【结 构 式】 
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【药物名称】 【化学名称】4-(Biphenyl-4-yloxy)-3-fluorobenzoic acid 【CA登记号】158770-36-6 【 分 子 式 】C19H13FO3 【 分 子 量 】308.31206 |
【开发单位】Yamanouchi (Originator) 【药理作用】Benign Prostatic Hyperplasia Therapy, RENAL-UROLOGIC DRUGS, Steroid 5alpha-Reductase Inhibitors |
合成路线1
The arylation of 4-phenylphenol (I) with 3,4-difluorobenzaldehyde (II) in the presence of K2CO3 in hot DMSO afforded diary ether (III). The target carboxylic acid was then obtained by oxidation of the aldehyde group of (III) by means of Ag2O, generated from AgNO3 and NaOH.
| 【1】 Fujii, M.; Naito, R.; Oritani, H.; Kimura, T.; Koutoku, H.; Hara, H.; Igarashi, S.; Mase, T.; A novel class of inhibitors for human steroid 5alpha-reductase: Phenoxybenzoic acid derivatives. I. Chem Pharm Bull 1999, 47, 8, 1073. |
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