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【结 构 式】 
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【分子编号】32405 【品名】dibenzyl (4S,7S,10S,15S,18S,21S)-10,15-bis{[((1S)-1-[(benzyloxy)carbonyl]-5-{[(benzyloxy)carbonyl]amino}pentyl)amino]carbonyl}-7,18-bis[2-(benzyloxy)-2-oxoethyl]-5,8,17,20-tetraoxo-4,21-bis({[(2S)-5-oxopyrrolidinyl]carbonyl}amino)-6,9,16,19-tetraazatetracosane-1,24-dioate 【CA登记号】 |
【 分 子 式 】C106H122N12O26 【 分 子 量 】1980.19996 【元素组成】C 64.29% H 6.21% N 8.49% O 21.01% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XVI)The condensation of tripeptide (XV) with intermediate tripeptide (VI) by means of TDBTU and DIEA in DMF gives the fully benzylated target compound, which is finally deprotected with H2 over Pd/C in DMF/AcOH.
| 【1】 Hiebl, J.; et al.; Large-scale synthesis of hematoregulatory nonapeptide SK&F 107647 by fragment coupling. J Pept Res 1999, 54, 1, 54. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (VI) | 32398 | dibenzyl (9S,12S,17S,20S)-12,17-diamino-3,11,18,26-tetraoxo-1,28-diphenyl-2,27-dioxa-4,10,19,25-tetraazaoctacosane-9,20-dicarboxylate | C50H64N6O10 | 详情 | 详情 | |
| (XV) | 32404 | (2S)-4-(benzyloxy)-2-[[(2S)-5-(benzyloxy)-5-oxo-2-([[(2S)-5-oxopyrrolidinyl]carbonyl]amino)pentanoyl]amino]-4-oxobutyric acid | C28H31N3O9 | 详情 | 详情 | |
| (XVI) | 32405 | dibenzyl (4S,7S,10S,15S,18S,21S)-10,15-bis{[((1S)-1-[(benzyloxy)carbonyl]-5-{[(benzyloxy)carbonyl]amino}pentyl)amino]carbonyl}-7,18-bis[2-(benzyloxy)-2-oxoethyl]-5,8,17,20-tetraoxo-4,21-bis({[(2S)-5-oxopyrrolidinyl]carbonyl}amino)-6,9,16,19-tetraazatetracosane-1,24-dioate | C106H122N12O26 | 详情 | 详情 |
Extended Information