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【结 构 式】

【分子编号】32224

【品名】2,4-diamino-5-methyl-6-quinazolinecarbonitrile

【CA登记号】

【 分 子 式 】C10H9N5

【 分 子 量 】199.21516

【元素组成】C 60.29% H 4.55% N 35.15%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

The reaction of 2,4,6-triamino-5-methylquinazoline (I) with NaNO2 and aqueous HCl gives the corresponding diazonium salt (II), which by a Sandmeyer reaction with cuprous cyanide in hot water yields 2,4-diamino-5-methylquinazoline-6-carbonitrile (III). Finally, this compound is reductocondensed with 3,4,5-trimethoxyaniline (IV) by means of H2 over Raney-Ni in acetic acid.

1 Elslager, E.F.; Werbel, L.M. (Pfizer Inc.); Quinazoline compounds and processes for their production. GB 1345502 .
2 Hillier, K.; Castañer, J.; Serradell, M.N.; Blancafort, P.; JB-11. Drugs Fut 1981, 6, 5, 282.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 32222 2,4-diamino-5-methyl-6-quinazolinylamine; 5-methyl-2,4,6-quinazolinetriamine C9H11N5 详情 详情
(II) 32223 2,4-diamino-5-methyl-6-quinazolinediazonium chloride C9H9ClN6 详情 详情
(III) 32224 2,4-diamino-5-methyl-6-quinazolinecarbonitrile C10H9N5 详情 详情
(IV) 31545 3,4,5-trimethoxyaniline; 3,4,5-trimethoxyphenylamine;3,4,5-Trimethoxybenzenamine;[3,4,5-Tris(methyloxy)phenyl]amine 24313-88-0 C9H13NO3 详情 详情
Extended Information