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【结 构 式】 
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【分子编号】32222 【品名】2,4-diamino-5-methyl-6-quinazolinylamine; 5-methyl-2,4,6-quinazolinetriamine 【CA登记号】 |
【 分 子 式 】C9H11N5 【 分 子 量 】189.22004 【元素组成】C 57.13% H 5.86% N 37.01% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)The reaction of 2,4,6-triamino-5-methylquinazoline (I) with NaNO2 and aqueous HCl gives the corresponding diazonium salt (II), which by a Sandmeyer reaction with cuprous cyanide in hot water yields 2,4-diamino-5-methylquinazoline-6-carbonitrile (III). Finally, this compound is reductocondensed with 3,4,5-trimethoxyaniline (IV) by means of H2 over Raney-Ni in acetic acid.
| 【1】 Elslager, E.F.; Werbel, L.M. (Pfizer Inc.); Quinazoline compounds and processes for their production. GB 1345502 . |
| 【2】 Hillier, K.; Castañer, J.; Serradell, M.N.; Blancafort, P.; JB-11. Drugs Fut 1981, 6, 5, 282. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 32222 | 2,4-diamino-5-methyl-6-quinazolinylamine; 5-methyl-2,4,6-quinazolinetriamine | C9H11N5 | 详情 | 详情 | |
| (II) | 32223 | 2,4-diamino-5-methyl-6-quinazolinediazonium chloride | C9H9ClN6 | 详情 | 详情 | |
| (III) | 32224 | 2,4-diamino-5-methyl-6-quinazolinecarbonitrile | C10H9N5 | 详情 | 详情 | |
| (IV) | 31545 | 3,4,5-trimethoxyaniline; 3,4,5-trimethoxyphenylamine；3,4,5-Trimethoxybenzenamine；[3,4,5-Tris(methyloxy)phenyl]amine | 24313-88-0 | C9H13NO3 | 详情 | 详情 |
Extended Information