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【结 构 式】 
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【分子编号】32197 【品名】6-(2-Bromoethyl)-2-naphthyl methyl ether; 2-(6-Methoxy-2-napthyl)ethyI bromide; 2-(2-Bromoethyl)-6-methoxynaphthalene 【CA登记号】 |
【 分 子 式 】C13H13BrO 【 分 子 量 】265.14962 【元素组成】C 58.89% H 4.94% Br 30.14% O 6.03% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(V)The reduction of methyl 6-methoxy-2-naphtyl acetate (III) with LiAlH4 in refluxing ether gives 2-(6-methoxy-2-naphthyl)ethanol (IV), which by treatment with PBr3 in refluxing benzene is converted into 2-(6-methoxy-2-naphthyl)ethyl bromide (V). The reaction of (V) with KCN in refluxing ethanol - water affords 3-(6-methoxy-2-naphthyl)propionitrile (VI), which is finally treated with methylmagnesium iodide in refluxing ethanol.
| 【1】 Goudie, A.C. Ert al.; 4-(6-Methoxy-2-naphtyl)butan-2-one and related analogues, a novel structural class of antiinflammatory compounds. J Med Chem 1978, 21, 12, 1260. |
| 【2】 Neuman, M.; Blancafort, P.; Castaner, J.; Serradell, M.N.; Nabumetone. Drugs Fut 1981, 6, 1, 35. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (III) | 32195 | 6-Methoxy-2-naphtyl acetate; 1-(6-Methoxy-2-naphthyl)acetone | C14H14O2 | 详情 | 详情 | |
| (IV) | 32196 | 2-(6-Methoxy-2-naphthyl)-1-ethanol | C13H14O2 | 详情 | 详情 | |
| (V) | 32197 | 6-(2-Bromoethyl)-2-naphthyl methyl ether; 2-(6-Methoxy-2-napthyl)ethyI bromide; 2-(2-Bromoethyl)-6-methoxynaphthalene | C13H13BrO | 详情 | 详情 | |
| (VI) | 32198 | 3-(6-Methoxy-2-naphthyl)propanenitrile; 3-(6-Methoxy-2-naphthyl)propionitrile | C14H13NO | 详情 | 详情 |
Extended Information