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【结 构 式】

【分子编号】32196

【品名】2-(6-Methoxy-2-naphthyl)-1-ethanol

【CA登记号】

【 分 子 式 】C13H14O2

【 分 子 量 】202.25296

【元素组成】C 77.2% H 6.98% O 15.82%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

The reduction of methyl 6-methoxy-2-naphtyl acetate (III) with LiAlH4 in refluxing ether gives 2-(6-methoxy-2-naphthyl)ethanol (IV), which by treatment with PBr3 in refluxing benzene is converted into 2-(6-methoxy-2-naphthyl)ethyl bromide (V). The reaction of (V) with KCN in refluxing ethanol - water affords 3-(6-methoxy-2-naphthyl)propionitrile (VI), which is finally treated with methylmagnesium iodide in refluxing ethanol.

1 Goudie, A.C. Ert al.; 4-(6-Methoxy-2-naphtyl)butan-2-one and related analogues, a novel structural class of antiinflammatory compounds. J Med Chem 1978, 21, 12, 1260.
2 Neuman, M.; Blancafort, P.; Castaner, J.; Serradell, M.N.; Nabumetone. Drugs Fut 1981, 6, 1, 35.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(III) 32195 6-Methoxy-2-naphtyl acetate; 1-(6-Methoxy-2-naphthyl)acetone C14H14O2 详情 详情
(IV) 32196 2-(6-Methoxy-2-naphthyl)-1-ethanol C13H14O2 详情 详情
(V) 32197 6-(2-Bromoethyl)-2-naphthyl methyl ether; 2-(6-Methoxy-2-napthyl)ethyI bromide; 2-(2-Bromoethyl)-6-methoxynaphthalene C13H13BrO 详情 详情
(VI) 32198 3-(6-Methoxy-2-naphthyl)propanenitrile; 3-(6-Methoxy-2-naphthyl)propionitrile C14H13NO 详情 详情
Extended Information