N-[2-([3-[4-(Benzyloxy)phenoxy]-2-hydroxypropyl]amino)ethyl]-4-morpholinecarboxamide; 1-(p-Benzyloxyphenoxy)-3-[2-(morpholinocarbonamido)ethylamino]-2-propanol -Drug Synthesis Database

【结构式】

【分子编号】32154

【品名】N-[2-([3-[4-(Benzyloxy)phenoxy]-2-hydroxypropyl]amino)ethyl]-4-morpholinecarboxamide; 1-(p-Benzyloxyphenoxy)-3-[2-(morpholinocarbonamido)ethylamino]-2-propanol

【CA登记号】

【分子式】C₂₃H₃₁N₃O₅

【分子量】429.51636

【元素组成】C 64.32% H 7.27% N 9.78% O 18.62%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The reaction of 1-(p-benzyloxyphenoxy)-2,3-epoxypropane (I) with 4-[N-(2-aminoethyl)carbamoyl]morpholine (II) by means of KOH in isopropanol gives 1-(p-benzyloxyphenoxy)-3-[2-(morpholinocarbonamido)ethylamino]-2-propanol (III), which is debenzylated by treatment with H2 over Pd/C in ethanol acetic acid and treated with a solution of fumaric acid in ethanol.

参考文献中间体

合成目标

【1】 Main, B.G.; Barlow, J.J. (AstraZeneca plc); Morpholine carboxamides and use thereof. FR 2391997; JP 53147038; US 4143140; US 4172150 .
【2】 Blancafort, P.; Serradell, M.N.; Thorpe, P.J.; Castaner, J.; ICI-118,587. Drugs Fut 1982, 7, 8, 571.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
	23808	Fumaric acid; (E)-2-butenedioic acid	110-17-8	C₄H₄O₄	详情	详情
(I)	32152	Benzyl 4-(2-oxiranyloxy)phenyl ether; 2-[4-(Benzyloxy)phenoxy]oxirane; 1-(p-Benzyloxyphenoxy)-2,3-epoxypropane		C₁₅H₁₄O₃	详情	详情
(II)	32153	N-(2-aminoethyl)-4-morpholinecarboxamide; 4-[N-(2-Aminoethyl)carbamoyl]morpholine		C₇H₁₅N₃O₂	详情	详情
(III)	32154	N-[2-([3-[4-(Benzyloxy)phenoxy]-2-hydroxypropyl]amino)ethyl]-4-morpholinecarboxamide; 1-(p-Benzyloxyphenoxy)-3-[2-(morpholinocarbonamido)ethylamino]-2-propanol		C₂₃H₃₁N₃O₅	详情	详情

Extended Information