7-chloro-5-(2-fluorophenyl)-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one -Drug Synthesis Database

【结构式】

【分子编号】31936

【品名】7-chloro-5-(2-fluorophenyl)-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one

【CA登记号】

【分子式】C₁₅H₁₀ClFN₂O₂

【分子量】304.7077832

【元素组成】C 59.13% H 3.31% Cl 11.63% F 6.23% N 9.19% O 10.5%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

7-Chloro-3-hydroxy-5-(2'-fluorophenyl)-1,3-(dihydro-2H-1,4-benzodiazepin-2-one (I) is mixed with acrylonitrile (II), and after dropwise addition of triethylbenzylammonium chloride (A) and benzyl trimethylammonium hydroxide (B), stirring is continued for 8 hours. The crude material was recrystallized from acetonitrile.

参考文献中间体

合成目标

【1】 Schlager, L.H. (Gerot Pharmazeutika GmbH); Novel 3-hydroxy-1,4-benzodiazepine-2-ones and process for the preparation thereof. AT 361492B; DE 2950235; ES 8103738; FR 2444672; US 4388313 .
【2】 Koch, H.; Cinolazepam. Drugs Fut 1982, 7, 2, 98.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(B)	27394	Trimethylbenzylammonium Hydroxide; N,N,N-trimethyl(phenyl)methanaminium hydroxide; Triton B; Benzyltrimethylammonium hydroxide	100-85-6	C₁₀H₁₇NO	详情	详情
(A)	31937	Triethylbenzylammonium chloride; N-benzyl-N,N-diethyl-1-ethanaminium chloride; Benzyltriethylammonium chloride	56-37-1	C₁₃H₂₂ClN	详情	详情
(I)	31936	7-chloro-5-(2-fluorophenyl)-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one		C₁₅H₁₀ClFN₂O₂	详情	详情
(II)	10847	Acrylonitrile	107-13-1	C₃H₃N	详情	详情

Extended Information