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【结 构 式】 
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【药物名称】Cinolazepam, OX-373, Gerodorm 【化学名称】7-Chloro-1-(2-cyanoethyl)-5-(2'-fluorophenyl)-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one 【CA登记号】75696-02-5 【 分 子 式 】C18H13ClFN3O2 【 分 子 量 】357.77461 |
【开发单位】Gerot (Originator) 【药理作用】PSYCHOPHARMACOLOGIC DRUGS, Sedative/Hypnotics, Sleep Disorders, Treatment of, Benzodiazepines, GABA(A) BZ Site Receptor Agonists |
合成路线1
7-Chloro-3-hydroxy-5-(2'-fluorophenyl)-1,3-(dihydro-2H-1,4-benzodiazepin-2-one (I) is mixed with acrylonitrile (II), and after dropwise addition of triethylbenzylammonium chloride (A) and benzyl trimethylammonium hydroxide (B), stirring is continued for 8 hours. The crude material was recrystallized from acetonitrile.
| 【1】 Schlager, L.H. (Gerot Pharmazeutika GmbH); Novel 3-hydroxy-1,4-benzodiazepine-2-ones and process for the preparation thereof. AT 361492B; DE 2950235; ES 8103738; FR 2444672; US 4388313 . |
| 【2】 Koch, H.; Cinolazepam. Drugs Fut 1982, 7, 2, 98. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (B) | 27394 | Trimethylbenzylammonium Hydroxide; N,N,N-trimethyl(phenyl)methanaminium hydroxide; Triton B; Benzyltrimethylammonium hydroxide | 100-85-6 | C10H17NO | 详情 | 详情 |
| (A) | 31937 | Triethylbenzylammonium chloride; N-benzyl-N,N-diethyl-1-ethanaminium chloride; Benzyltriethylammonium chloride | 56-37-1 | C13H22ClN | 详情 | 详情 |
| (I) | 31936 | 7-chloro-5-(2-fluorophenyl)-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one | C15H10ClFN2O2 | 详情 | 详情 | |
| (II) | 10847 | Acrylonitrile | 107-13-1 | C3H3N | 详情 | 详情 |