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【结 构 式】 
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【分子编号】31718 【品名】ethyl 2-chloroethyl(methyl)carbamate 【CA登记号】 |
【 分 子 式 】C6H12ClNO2 【 分 子 量 】165.61952 【元素组成】C 43.51% H 7.3% Cl 21.41% N 8.46% O 19.32% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VIII)beta-Methylaminoethanol (VI) is treated with ethyl chlorocarbonate in triethylamine to give ethyl N-methyl-hydroxyethylcarbamate (VII), which is treated with thionyl chloride to give ethyl-N-methyl-beta-chloroethylcarbamate (VIII). Compound (VIII) is treated with 5H-dibenzo[a,d]cyclohepten-5-one oxime (I) and the resulting product is decomposed without isolation.
| 【1】 Pirola, O.; Rossi, S.; Fanelli, O.; Maggi, R.; O- And N- substituted 5H-dibenzo[a,d]cyclohepten-5-one oximes with thymoleptic acticity. VII. Synthesis and pharmacological properties of the substituted oximes. Farm Sci Ed 1969, 24, 7, 685-703. |
| 【2】 Castaner, J.; Serradell, M.N.; Blancafort, P.; Demexiptiline hydrochloride. Drugs Fut 1982, 7, 1, 19. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 31713 | 5H-dibenzo[a,d]cyclohepten-5-one oxime | C15H11NO | 详情 | 详情 | |
| (VI) | 13324 | 2-Methylaminoethanol; 2-(Methylamino)-1-ethanol | 109-83-1 | C3H9NO | 详情 | 详情 |
| (VII) | 31717 | ethyl 2-hydroxyethyl(methyl)carbamate | C6H13NO3 | 详情 | 详情 | |
| (VIII) | 31718 | ethyl 2-chloroethyl(methyl)carbamate | C6H12ClNO2 | 详情 | 详情 |
Extended Information