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【结 构 式】

【分子编号】31717

【品名】ethyl 2-hydroxyethyl(methyl)carbamate

【CA登记号】

【 分 子 式 】C6H13NO3

【 分 子 量 】147.17416

【元素组成】C 48.97% H 8.9% N 9.52% O 32.61%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(VII)

beta-Methylaminoethanol (VI) is treated with ethyl chlorocarbonate in triethylamine to give ethyl N-methyl-hydroxyethylcarbamate (VII), which is treated with thionyl chloride to give ethyl-N-methyl-beta-chloroethylcarbamate (VIII). Compound (VIII) is treated with 5H-dibenzo[a,d]cyclohepten-5-one oxime (I) and the resulting product is decomposed without isolation.

1 Pirola, O.; Rossi, S.; Fanelli, O.; Maggi, R.; O- And N- substituted 5H-dibenzo[a,d]cyclohepten-5-one oximes with thymoleptic acticity. VII. Synthesis and pharmacological properties of the substituted oximes. Farm Sci Ed 1969, 24, 7, 685-703.
2 Castaner, J.; Serradell, M.N.; Blancafort, P.; Demexiptiline hydrochloride. Drugs Fut 1982, 7, 1, 19.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 31713 5H-dibenzo[a,d]cyclohepten-5-one oxime C15H11NO 详情 详情
(VI) 13324 2-Methylaminoethanol; 2-(Methylamino)-1-ethanol 109-83-1 C3H9NO 详情 详情
(VII) 31717 ethyl 2-hydroxyethyl(methyl)carbamate C6H13NO3 详情 详情
(VIII) 31718 ethyl 2-chloroethyl(methyl)carbamate C6H12ClNO2 详情 详情
Extended Information