[1,1'-biphenyl]-4-yl(phenyl)methanone -Drug Synthesis Database

【结构式】

【分子编号】31709

【品名】[1,1'-biphenyl]-4-yl(phenyl)methanone

【CA登记号】2128-93-0

【分子式】C₁₉H₁₄O

【分子量】258.31956

【元素组成】C 88.34% H 5.46% O 6.19%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

The reduction of 4-phenylbenzophenone (I) with NaBH4 in ethanol gives 4-phenylbenzhydrol (II), which is then condensed with imidazole (III) by means of SOCl2 in acetonitrile.

参考文献中间体

合成目标

【1】 Regel, E.; Draber, W.; Buechel, K.H.; Plempel, M. (Bayer AG); alpha-(4-Biphenylyl)-benzylazolium salts and their use for combating microorganisms. BE 0859041; DE 2643563; FR 2365559; GB 1535148; JP 53044568; NL 7710489; US 4243670 .
【2】 Regel, E.; Draber, W.; Buechel, K.H.; Plempel, M. (Bayer AG); Substituted azol-1-ylmethanes. BE 0836924; CA 1059134; CH 619454; DD 124729; DE 2461406; FR 2295747; GB 1469617; JP 51091260; NL 7514940; US 4118487 .
【3】 Regel, E.; Draber, W.; Buechel, K.H.; Plempel, M. (Bayer AG); Combating crop damaging fungi with alpha-(4-biphenylyl)-benzyl-azolium salts. DE 2714290; JP 53121941; US 4251540 .
【4】 Serradell, M.N.; Blancafort, P.; Castaner, J.; Bifonazole. Drugs Fut 1982, 7, 2, 87.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	31709	[1,1'-biphenyl]-4-yl(phenyl)methanone	2128-93-0	C₁₉H₁₄O	详情	详情
(II)	31710	[1,1'-biphenyl]-4-yl(phenyl)methanol		C₁₉H₁₆O	详情	详情
(III)	10255	Imidazole; 1H-Imidazole	288-32-4	C₃H₄N₂	详情	详情

Extended Information