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【结 构 式】 
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【分子编号】31465 【品名】2-cyclopentyl-2-hydroxy-2-phenylacetic acid; alpha-Cyclopentylmandelic acid 【CA登记号】427-49-6 |
【 分 子 式 】C13H16O3 【 分 子 量 】220.26824 【元素组成】C 70.89% H 7.32% O 21.79% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(V)Racemic 2-cyclopentyl-2-hydroxy-2-phenylacetic acid (V) was resolved by recrystallization of its cinchonidine salt from toluene to furnish the (-)-(R)-enantiomer (VI). Coupling with amine (IV) by means of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (EDC) and 1-hydroxybenzotriazole (HOBt) then gave the target amide.
| 【1】 Mase, T.; Mitsuya, M.; Tsuchiya, Y.; et al.; J-104129, a novel muscarinic M3 receptor antagonist with high selectivity for M3 over M2 receptors. Bioorg Med Chem 1999, 7, 11, 2555. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IV) | 31463 | 1-(4-methyl-3-pentenyl)-4-piperidinamine; 1-(4-methyl-3-pentenyl)-4-piperidinylamine | C11H22N2 | 详情 | 详情 | |
| (V) | 31465 | 2-cyclopentyl-2-hydroxy-2-phenylacetic acid; alpha-Cyclopentylmandelic acid | 427-49-6 | C13H16O3 | 详情 | 详情 |
| (VI) | 31466 | (2R)-2-cyclopentyl-2-hydroxy-2-phenylethanoic acid | C13H16O3 | 详情 | 详情 |
Extended Information